Summary
Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.
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16 November 2011
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Silva, J., Dominguez, G., Villanueva, M. et al. Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer 80, 1262–1264 (1999). https://doi.org/10.1038/sj.bjc.6690495
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DOI: https://doi.org/10.1038/sj.bjc.6690495
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