Abstract
Salivary function, dental caries and caries-associated salivary microorganisms were investigated in children undergoing BMT during a 4-year longitudinal study. Fourteen children were conditioned with CY and TBI and 12 with CY with or without BU. Four years after BMT the mean salivary secretion rate was 1.3 ± 0.7 ml/min in the chemotherapy group, compared to 0.7 ± 0.5 in the TBI/CY group (P < 0.05). the mean salivary secretion rate fell from 0.9 ± 0.5 ml/min before tbi to 0.2 ± 0.1 after 3 months (P < 0.01), 0.3 ± 0.3 ml/min after 6 months (P < 0.01) and 0.5 ± 0.6, 1 year after tbi (P < 0.05). mean reduction in stimulated salivary flow 3 months after tbi was 78% in the tbi/cy group compared to 36% in the chemotherapy group (P < 0.05). children conditioned with chemotherapy showed an increased salivary flow compared to baseline; this was not found in tbi-treated children, suggesting that damage to the salivary glands may be permanent. four years after bmt, children conditioned with tbi had significantly higher counts of mutans streptococci (P < 0.05) and lactobacilli (P < 0.01) compared to age-matched controls. however, the prevalence of dental caries did not differ between children conditioned with tbi, chemotherapy and healthy controls.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dahllöf, G., Bågesund, M. & Ringdén, O. Impact of conditioning regimens on salivary function, caries-associated microorganisms and dental caries in children after bone marrow transplantation. A 4-year longitudinal study. Bone Marrow Transplant 20, 479–483 (1997). https://doi.org/10.1038/sj.bmt.1700919
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700919
Keywords
This article is cited by
-
Dental abnormalities after chemotherapy in long-term survivors of childhood acute lymphoblastic leukemia 7–40 years after diagnosis
Supportive Care in Cancer (2016)
-
Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT
Bone Marrow Transplantation (2013)
-
Salivary secretion in children after fractionated or single-dose TBI
Bone Marrow Transplantation (2012)
-
A systematic review of dental disease in patients undergoing cancer therapy
Supportive Care in Cancer (2010)
-
A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life
Supportive Care in Cancer (2010)