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CD34+ Cell Selected Transplants

Allogeneic transplantation of CD34+-selected cells from peripheral blood in patients with myeloid malignancies in early phase: a case control comparison with unmodified peripheral blood transplantation

Bone Marrow Transplantation volume 28, pages 349–354 (2001)Cite this article

Abstract

An allogeneic transplantation of CD34+-selected cells from peripheral blood (allo-PBT/CD34+) from HLA-identical sibling donors was performed in 50 adult patients with acute myeloid leukemia in first complete remission (AML CR1) (n = 29), myelodysplastic syndrome (MDS) (n = 4), or chronic myeloid leukemia in first chronic phase (CML CP1) (n = 17). Clinical results were compared to a concurrent group of 50 patients transplanted with unmodified peripheral blood progenitor cells (allo-PBT), matched for age, diagnosis, and disease stage. The median follow-up period was 29 months (range 1–69). The actuarial probability of developing acute GVHD clinical grade II to IV was 16% (95%CI: 6–26) for the allo-PBT/CD34+ group and 41% (95%CI: 29–57) for the allo-PBT group (P = 0.002). The actuarial probability of developing extensive chronic GVHD was 22% (95%CI: 8–36) for the allo-PBT/CD34+ group and 47% (95%CI: 31–63) for the allo-PBT group (P = 0.02). Recipients of allo-PBT/CD34+ had less toxicity associated with the transplant and better Karnofsky index at the last follow-up. For AML/MDS patients, the actuarial probability of disease-free survival (DFS) for recipients of allo-PBT/CD34+ and allo-PBT was 65% (95%CI: 45–85) vs43% (95%CI: 28–58) (P = 0.05), respectively. These data provide a rationale for a randomised trial of allo-PBT/CD34+ vs allo-PBT in AML/MDS patients in early stage of the disease. Bone Marrow Transplantation (2001) 28, 349–354.

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Acknowledgements

This work has been supported in part by grants FIJC-99/P-CR, FIJC-00/P-EM, from the José Carreras International Foundation and FIS-98/0995, FIS-98/0380 from the Fondo de Investigaciones Sanitarias de la Seguridad Social, Spanish Ministry of Health.

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Authors and Affiliations

  1. Hospital Clinic, Barcelona, Spain

    A Urbano-Ispizua, M Rovira, C Riu, C Rozman & E Montserrat

  2. Hospital Clínico, Valencia, Spain

    C Solano & J García-Conde

  3. Hospital La Fe, Valencia, Spain

    J de la Rubia

  4. Hospital Sant Pau, Barcelona, Spain

    S Brunet

  5. Hospital Ramón y Cajal, Madrid, Spain

    J Pérez de Oteiza & J Odriozola

  6. Hospital Duran i Reynals, Barcelona, Spain

    C Ferrá

  7. Hospital Vall d'Hebron, Barcelona, Spain

    J Zuazu

  8. Hospital Clínico, Salamanca, Spain

    D Caballero

  9. Hospital Gregorio Marañón, Madrid, Spain

    JL Díez-Martín

  10. Hospital Virgen del Rocío, Sevilla, Spain

    I Espigado

  11. Hospital General, Murcia, Spain

    JM Moraleda

  12. Hospital Juan Canalejo, Coruña, Spain

    P Torres

  13. Hospital Son Dureta, Mallorca, Spain

    J Bargay

  14. Hospital La Paz, Madrid, Spain

    E Ojeda & J Sierra

  15. Hospital La Princesa, Mardid, Spain

    A Alegre

  16. Hospital 12 de Octubre, Madrid, Spain

    J de la Serna

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  1. A Urbano-Ispizua
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Urbano-Ispizua, A., Brunet, S., Solano, C. et al. Allogeneic transplantation of CD34+-selected cells from peripheral blood in patients with myeloid malignancies in early phase: a case control comparison with unmodified peripheral blood transplantation. Bone Marrow Transplant 28, 349–354 (2001). https://doi.org/10.1038/sj.bmt.1703154

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  • DOI: https://doi.org/10.1038/sj.bmt.1703154

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