Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

Bone Marrow Transplantation volume 29, pages 999–1003 (2002)Cite this article

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34+ cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Leone G, Mele L, Pulsoni A et al. The incidence of secondary leukemias Haematologica 1999 84: 937 945

    CAS  PubMed  Google Scholar 

  2. Kantarjian HM, Keating MJ, Walters RS et al. Therapy-related leukemia and myelodysplastic syndrome: clinical, cytogenetic, and prognostic features J Clin Oncol 1986 4: 1748 1757

    Article  CAS  PubMed  Google Scholar 

  3. Heim S . Cytogenetic findings in primary and secondary MDS Leuk Res 1992 16: 43 46

    Article  CAS  PubMed  Google Scholar 

  4. Larson RA, LeBeau MM, Vardiman JW, Rowley JD . Myeloid leukemia after hematotoxins Environ Health Perspect 1996 104: (Suppl. 6) 1303 1307

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Deeg HJ, Appelbaum FR . Hemopoietic stem cell transplantation for myelodysplastic syndrome Curr Opin Oncol 2000 12: 116 120

    Article  CAS  PubMed  Google Scholar 

  6. Arnold R, de Witte T, van Biezen A et al. Unrelated bone marrow transplantation in patients with myelodysplastic syndromes and secondary acute myeloid leukemia: an EBMT survey. European Blood and Marrow Transplantation Group Bone Marrow Transplant 1998 21: 1213 1216

    Article  CAS  PubMed  Google Scholar 

  7. Witherspoon RP, Deeg HJ . Allogeneic bone marrow transplantation for secondary leukemia or myelodysplasia Haematologica 1999 84: 1085 1087

    CAS  PubMed  Google Scholar 

  8. Nevill TJ, Shepherd JD, Brockington DA et al. Outcome analysis and risk factors predictive of survival in stem cell transplantation (SCT) for therapy-induced myelodysplastic syndrome/acute myelogenous leukemia (tMDS/AML) Blood 2001 98: 625a (Abstr.)

    Google Scholar 

  9. Fialkow PJ, Thomas ED, Bryant JI, Neiman PE . Leukaemic transformation of engrafted human marrow cells in vivo Lancet 1971 i: 251 255

    Article  Google Scholar 

  10. Blazar BR, Orr HT, Arthur DC et al. Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation Blood 1985 66: 1436 1444

    CAS  PubMed  Google Scholar 

  11. Budowle B, Chakraborty R, Giusti AM et al. Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE Am J Hum Genet 1991 48: 137 144

    CAS  PubMed  PubMed Central  Google Scholar 

  12. McCann SR, Lawler M, Humphries P et al. Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia: confirmation by microsatellite studies Blood 1992 79: 2803 2805

    CAS  PubMed  Google Scholar 

  13. Mitelman F . ISCN (1995) An International System for Human Cytogenetic Nomenclature Karger: Basel 1995 1995

    Google Scholar 

  14. Pedersen-Bjergaard J, Andersen MK, Christiansen DH . Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation Blood 2000 95: 3273 3279

    CAS  PubMed  Google Scholar 

  15. Krishnan A, Bhatia S, Slovak ML et al. Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors Blood 2000 95: 1588 1593

    CAS  PubMed  Google Scholar 

  16. Milligan DW, Ruiz De Elvira MC, Kolb HJ et al. Secondary leukaemia and myelodysplasia after autografting for lymphoma: results from the EBMT. EBMT Lymphoma and Late Effects Working Parties. European Group for Blood and Marrow Transplantation Br J Haematol 1999 106: 1020 1026

    Article  CAS  PubMed  Google Scholar 

  17. Van Den Neste E, Louviaux I, Michaux JL et al. Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2′-deoxyadenosine Br J Haematol 1999 105: 268 270

    CAS  PubMed  Google Scholar 

  18. Thomas ED, Buckner CD, Fefer A et al. Leukaemic transformation of engrafted human marrow cells in vivo Lancet 1972 i: 1310 1313

    Article  Google Scholar 

  19. Schmitz N, Johannson W, Schmidt G et al. Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6 Blood 1987 70: 1099 1104

    CAS  PubMed  Google Scholar 

  20. Cooley LD, Sears DA, Udden MM et al. Donor cell leukemia: report of a case occuring 11 years after allogeneic bone marrow transplantation and review of the literature Am J Hematol 2000 63: 46 53

    Article  CAS  PubMed  Google Scholar 

  21. Witherspoon RP, Schubach W, Neiman PE et al. Donor cell leukemia developing six years after marrow grafting for acute leukemia Blood 1985 65: 1172 1174

    CAS  PubMed  Google Scholar 

  22. Mielcarek M, Bryant E, Loken M et al. Haemopoietic reconstitution by donor-derived myelodysplastic progenitor cells after haemopoietic stem cell transplantation Br J Haematol 1999 105: 361 365

    Article  CAS  PubMed  Google Scholar 

  23. Niederwieser DW, Appelbaun FR, Gastl G et al. Inadvertent transmission of a donor's acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia New Engl J Med 1990 322: 1794 1796

    Article  CAS  PubMed  Google Scholar 

  24. Duhrsen U, Hossfeld DK . Stromal abnormalities in neoplastic bone marrow diseases Ann Hematol 1996 73: 53 70

    Article  CAS  PubMed  Google Scholar 

  25. McCann SR, Lawler M, Bacigalupo A . Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia Leuk Lymphoma 1993 10: 419 425

    Article  CAS  PubMed  Google Scholar 

  26. Simmons PJ, Przepiorka D, Thomas ED et al. Host origin of marrow stromal cells following allogeneic bone marrow transplantation Nature 1987 328: 429 432

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology, Department of Medicine University of Minnesota, Oncology and Transplantation, Minneapolis, MN, USA

    CG Brunstein, D Hammerschmidt & CM Verfaillie

  2. Department of Laboratory Medicine and Pathology, Cytogenetics Laboratory, University of Minnesota, Minneapolis, MN, USA

    BA Hirsch

  3. Department of Laboratory Medicine and Pathology, Molecular Diagnostics Laboratory, University of Minnesota, Minneapolis, MN, USA

    RC McGlennen

  4. Department of Laboratory Medicine and Pathology, Special Hematology Laboratory, University of Minnesota, Minneapolis, MN, USA

    PL Nguyen

  5. Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA

    CM Verfaillie

Authors
  1. CG Brunstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. BA Hirsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D Hammerschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. RC McGlennen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. PL Nguyen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. CM Verfaillie
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brunstein, C., Hirsch, B., Hammerschmidt, D. et al. Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplant 29, 999–1003 (2002). https://doi.org/10.1038/sj.bmt.1703577

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703577

Keywords

This article is cited by

Search

Advanced search

Quick links