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Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit–vegetable-concentrate containing antioxidant polyphenols

European Journal of Clinical Nutrition volume 55, pages 786–792 (2001)Cite this article

Abstract

Objective: To investigate whether antioxidant polyphenols from fruit juices or a fruit–vegetable-concentrate increase the plasma antioxidant capacity in HIV-infected and healthy subjects.

Design: Twenty-three HIV-seropositive and 18 seronegative adults were randomized to ingest either 1 l of fruit juice or 30 ml fruit–vegetable-concentrate per day over 16 weeks in addition to their normal Western diet.

Methods: Plasma antioxidant capacity was determined as Trolox equivalent antioxidant capacity (TEAC) at baseline, after 1 and 16 weeks of intervention, and after a 6 week washout.

Results: There was no difference in plasma antioxidant capacity between HIV-infected and healthy subjects at baseline (P=0.1). After 16 weeks of intervention TEAC increased in HIV-positive subjects with both types of polyphenol supplementation (juice, 1.38±0.07 to 1.42±0.04 mM, P=0.034; concentrate, 1.40±0.09 to 1.46±0.08 mM, P=0.025). TEAC was not altered by either type of supplementation in HIV-seronegative subjects.

Conclusion: Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit–vegetable-concentrate in HIV-seropositive but not in HIV-seronegative subjects.

Sponsorship: This study was supported by a grant and Cellagon aurum® from HG Berner GmbH, Altenholz, and fruit juices from Eckes Granini GmbH & Co. KG, Nieder-Olm.

European Journal of Clinical Nutrition (2001) 55, 786–792

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Author notes

  1. R Goerlich: Guarantor: R Goerlich.

  2. BM Arendt, AM Boetzer, H Lemoch, P Winkler, JK Rockstroh, HK Berthold, U Spengler and R Goerlich: Contributors: BMA carried out the laboratory research, did the statistical analysis together with HKB, and wrote this paper. The idea for this project was developed by RG, US, PW and AMB. US and JKR supervised the study as clinical investigators. AMB designed and evaluated the food questionnaires and was involved in the coordination of the study. HL was concerned with establishing the TEAC assay

Authors and Affiliations

  1. Department of Hemostasis and Transfusion Medicine, School of Medicine, University of Düsseldorf, Düsseldorf, Germany

    BM Arendt, AM Boetzer, P Winkler & R Goerlich

  2. Department of General Internal Medicine 1, University of Bonn, Bonn, Germany

    AM Boetzer, JK Rockstroh & U Spengler

  3. Institute for Clinical Biochemistry, University of Bonn, Bonn, Germany

    H Lemoch

  4. Department of Clinical Pharmacology, University of Bonn, Bonn, Germany

    HK Berthold

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  1. BM Arendt
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Arendt, B., Boetzer, A., Lemoch, H. et al. Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit–vegetable-concentrate containing antioxidant polyphenols. Eur J Clin Nutr 55, 786–792 (2001). https://doi.org/10.1038/sj.ejcn.1601227

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  • DOI: https://doi.org/10.1038/sj.ejcn.1601227

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