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Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial

European Journal of Clinical Nutrition volume 61, pages 1442–1444 (2007)Cite this article

Abstract

Objective:

The aim of this study was to verify if six months of isoflavone supplementation could increase fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height2) in obese–sarcopenic postmenopausal women.

Design:

Double-blind randomized study.

Subject:

Eighteen sarcopenic–obese women completed the study (12 on isoflavones and six on placebo). Body composition was measured by dual-energy X-ray absorptiometry. Subjects ingested 70 mg of isoflavones per day (44 mg of diadzein, 16 mg glycitein and 10 mg genestein) or a placebo for 24 weeks.

Results:

The isoflavone group increased significantly appendicular (P=0.034), leg (P=0.016) FFM and MMI (P=0.037), but not the placebo group.

Conclusion:

Six months of isoflavone supplementation increased FFM and MMI in obese–sarcopenic postmenopausal women.

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Authors and Affiliations

  1. Research Centre on Aging, Sherbrooke, Québec, Canada

    C Lord & I J Dionne

  2. Faculty of Physical Education and Sports, Sherbrooke, Québec, Canada

    M Aubertin-Leheudre & I J Dionne

  3. Department of Medicine, University of Sherbrooke, Sherbrooke, Québec, Canada

    A Khalil

Authors
  1. M Aubertin-Leheudre
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  2. C Lord
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  3. A Khalil
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  4. I J Dionne
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Correspondence to I J Dionne.

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Aubertin-Leheudre, M., Lord, C., Khalil, A. et al. Six months of isoflavone supplement increases fat-free mass in obese–sarcopenic postmenopausal women: a randomized double-blind controlled trial. Eur J Clin Nutr 61, 1442–1444 (2007). https://doi.org/10.1038/sj.ejcn.1602695

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602695

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