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IL-6 promoter polymorphisms in rheumatoid arthritis

Genes & Immunity volume 1, pages 338–340 (2000)Cite this article

Abstract

We investigated the possible association between the IL-6 promoter polymorphisms, at positions −622 and −174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The −622 and −174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.

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Authors and Affiliations

  1. Instituto de Parasitología y Biomedicina “López Neyra”, CSIC, Granada, Spain

    M Pascual, A Nieto & J Martín

  2. Servicio de Reumatología, Hospital Virgen de las Nieves, Granada, Spain

    L Matarán

  3. Hospital Universitario La Paz, Universidad Autónoma, Madrid, Spain

    A Balsa & D Pascual-Salcedo

Authors
  1. M Pascual
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  2. A Nieto
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  3. L Matarán
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  4. A Balsa
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  5. D Pascual-Salcedo
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  6. J Martín
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Corresponding author

Correspondence to J Martín.

Additional information

This work was supported by grant SAF97-0046 from Plan Nacional de I+D (CICYT) and in part from P.A.I. (CTS-180).

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Pascual, M., Nieto, A., Matarán, L. et al. IL-6 promoter polymorphisms in rheumatoid arthritis. Genes Immun 1, 338–340 (2000). https://doi.org/10.1038/sj.gene.6363677

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  • DOI: https://doi.org/10.1038/sj.gene.6363677

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