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Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT

Genes & Immunity volume 6, pages 162–166 (2005)Cite this article

Abstract

A growing body of evidence indicates that genetic factors are involved in an increased risk of infection. We investigated whether mannose-binding lectin (MBL) gene polymorphisms that cause low levels of MBL are associated with the occurrence of major infections in patients, mainly bearing hematological malignancies, after high-dose chemotherapy (HDT) rescued by autologous peripheral blood stem cell transplantation (auto-PBSCT). A retrospective evaluation of 113 patients treated with HDT and auto-PBSCT revealed that the low-producing genotypes, B/B and B/LXA, were associated with major bacterial infection (P=0.0016, OR 7.9). We next performed a nation-wide large-scale study to assess the allele frequency of the MBL coding mutation in a total of 2623 healthy individuals in Japan. The frequency of allele B was estimated to be ∼0.2, almost the same in seven different areas of Japan. This common occurrence suggests that MBL deficiency may play an important role in the clinical settings of immunosuppression.

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Authors and Affiliations

  1. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    T Horiuchi, H Gondo, H Miyagawa, J Otsuka, K Nagafuji, K Takase, H Tsukamoto, T Koyama, H Mitoma, Y Tamimoto, Y Miyagi, C Hashimura & M Harada

  2. Department of Blood Transfusion, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    S Inaba

  3. Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    T Tahira & K Hayashi

  4. Clinical Research Center, National Kyushu Medical Center Hospital, Fukuoka, Japan

    S Okamura

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  1. T Horiuchi
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  2. H Gondo
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  3. H Miyagawa
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  17. M Harada
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Correspondence to T Horiuchi.

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Horiuchi, T., Gondo, H., Miyagawa, H. et al. Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT. Genes Immun 6, 162–166 (2005). https://doi.org/10.1038/sj.gene.6364165

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  • DOI: https://doi.org/10.1038/sj.gene.6364165

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