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Evidence for joint action of genes on diabetes status and CVD risk factors in American Indians: the Strong Heart Family Study

International Journal of Obesity volume 27, pages 491–497 (2003)Cite this article

Abstract

OBJECTIVES: Previous research among American Indians of the strong heart family study (SHFS) has demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes. Moreover, we recently demonstrated that genetic effects on CVD risk factors differed in diabetic and nondiabetic individuals. In this paper, we investigated whether a significant genetic influence on diabetes status could be identified, and whether there is evidence for joint action of genes on diabetes status and related CVD risk factors.

METHODS AND RESULTS: Approximately 950 men and women, age 18 or older, in 32 extended families, were examined between 1997 and 1999. We estimated the effects of genes and environmental covariates on diabetes status using a threshold model and a maximum likelihood variance component approach. Diabetes status exhibited a residual heritability of 22% (h2=0.22). We also estimated the genetic and environmental correlations between diabetes susceptibility and eight risk factors for CVD. All eight CVD risk factors displayed significant genetic correlations with diabetes status (BMI (ρG=0.55), fibrinogen (ρG=0.40), HDL-C (ρG=−0.37), ln triglycerides (ρG=0.65), FAT (ρG=0.38), PAI-1 (ρG=0.67), SBP (ρG=0.57), and WHR (ρG=0.58)). Three of eight traits (HDL-C (ρE=−0.32), ln triglycerides (ρE=0.33), and fibrinogen (ρE=0.20)) displayed significant environmental correlations with diabetes status.

CONCLUSIONS: These findings suggest that in the context of a high prevalence of diabetes, still unidentified diabetes genes may play an important role in influencing variation in CVD risk factors.

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Acknowledgements

We thank the Strong Heart Family Study participants. Without their participation, this project would not have been possible. In addition, the cooperation of the Indian Health Service hospitals and clinics, and the directors of the Strong Heart Study clinics, Betty Jarvis, Marcia O'Leary, Dr Tauqeer Ali, Alan Crawford, and the many collaborators and staff of the Strong Heart Study have made this project possible. We also thank Drs John Blangero, Laura Almasy, Tony Comuzzie, and Lisa Martin for their generous contribution to this research. This research was conducted while author (KEN) was a postdoctoral fellow at the Southwest Foundation for Biomedical Research and was funded by a cooperative agreement that includes Grants U01 HL65520, U01 HL41642, U01 HL41652, U01 HL41654, U01 HL65521 from the National Heart, Lung, and Blood Institute. The views expressed in this paper are those of the authors and do not necessarily reflect those of the Indian Health Service.

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Authors and Affiliations

  1. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA

    K E North

  2. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA

    J T Williams & J W MacCluer

  3. Aberdeen Area Tribal Chairmen's Health Board, Rapid City, SD, USA

    T K Welty

  4. Missouri Breaks Industries Research, Inc., Timber Lake, SD, USA

    L G Best

  5. Center for American Indian Health Research, School of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    E T Lee

  6. Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, MD, USA

    R R Fabsitz

  7. MedStar Research Institute, Washington, DC, USA

    B V Howard

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North, K., Williams, J., Welty, T. et al. Evidence for joint action of genes on diabetes status and CVD risk factors in American Indians: the Strong Heart Family Study. Int J Obes 27, 491–497 (2003). https://doi.org/10.1038/sj.ijo.0802261

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