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  • Original Article
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Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

International Journal of Obesity volume 30, pages 1623–1631 (2006)Cite this article

Abstract

Objective:

To examine the relationship between body mass index (BMI) and waist–hip ratio (WHR) with serum levels of insulin-like growth factor-I (IGF-I), and its binding protein (IGFBP)-3.

Design:

Cross-sectional study on 2139 women participating in a case–control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3.

Results:

Adjusted mean serum IGF-I values were lower in women with BMI<22.5 kg/m2 or BMI>29.2 kg/m2 compared to women with BMI within this range (Pheterogeneity<0.0001, Ptrend=0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (Ptrend=0.005).

Conclusions:

Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to non-obese women and inversely related to central adiposity.

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Acknowledgements

The case–control study on breast cancer and endogenous hormones nested within EPIC was funded by the US Army Medical Research and Material Command (DAMD17-01-0275). Dr Gram's work at the International Agency for Research on Cancer, Lyon, France was funded by the Norwegian Research Council (Visiting Scientist Award grant 148365/300). The EPIC study was funded by ‘Europe Against Cancer’ Programme of the European Commission (SANCO); Ligue contre le Cancer (France); Société 3M (France); Mutuelle Générale de l’Education Nationale; Institut National de la Santé et de la Recherche Médicale (INSERM); German Cancer Aid; German Cancer Research Center; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; the participating regional governments and institutions of Spain; Cancer Research UK; Medical Research Council, UK; the Stroke Heterogeneity, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; the Wellcome Trust, UK; Greek Ministry of Health; Greek Ministry of Education; Italian Heterogeneity for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; Dutch Ministry of Health; Dutch Prevention Funds; LK Research Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Norwegian Cancer Society.

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Authors and Affiliations

  1. Institute of Community Medicine, School of Medicine, University of Tromsø, Tromsø, Norway

    I T Gram

  2. International Agency for Research on Cancer, Lyon, Cedex, France

    I T Gram, T Norat, S Rinaldi, L Dossus, C Casagrande, E Riboli & R Kaaks

  3. New York University School of Medicine, New York, USA

    A Lukanova

  4. Institut National de la Santé et de la Recherche Médicale (INSERM) U521, Institut Gustave Roussy, Villejuif, France

    B Téhard & F Clavel-Chapelon

  5. Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands

    C H van Gils, P A H van Noord & P H M Peeters

  6. Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

    H B Bueno-de-Mesquita

  7. Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany

    G Nagel & J Linseisen

  8. Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany

    P H Lahmann & H Boeing

  9. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Centre, Scientific Institute of Tuscany, Florence, Italy

    D Palli

  10. CPO-Piemonte, Torino, Italy

    C Sacerdote

  11. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

    S Panico

  12. Cancer Registry, Azienda Ospedaliera ‘Civile M.P. Arezzo’, Ragusa, Italy

    R Tumino

  13. Epidemiology Unit, Istituto Tumori, Milan, Italy

    S Sieri

  14. Subdirección de Salud Pública de Gipuzkoa, San Sebastian, Spain

    M Dorronsoro

  15. Sección Información Sanitaria, Consejería de Salud y Servicios Sanitarios de Asturias, Asturias, Spain

    J R Quirós

  16. Consejería de Sanidad y Consumo, Murcia, Spain

    C A Navarro & M-J Tormo

  17. Public Health Institute of Navarra, Oxford, Spain

    A Barricarte

  18. Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain

    C A González

  19. Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

    K Overvad

  20. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

    S Paaske Johnsen

  21. Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark

    A Olsen & A Tjønneland

  22. Epidemiology Unit, Cancer Research UK, University of Oxford, Pamplona, UK

    R Travis & N Allen

  23. MRC Dunn Nutrition Unit, Cambridge, UK

    S Bingham

  24. Institute of Public Health, University of Cambridge, Cambridge, UK

    K-T Khaw

  25. University of Umeå, UMEÅ, Sweden

    P Stattin

  26. University of Athens Medical School, Athens, Greece

    A Trichopoulou, V Kalapothaki & T Psaltopoulou

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Correspondence to R Kaaks.

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Gram, I., Norat, T., Rinaldi, S. et al. Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women. Int J Obes 30, 1623–1631 (2006). https://doi.org/10.1038/sj.ijo.0803324

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