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The ‘beneficial’ adipokines in reproduction and fertility

International Journal of Obesity volume 32, pages 223–231 (2008)Cite this article

Abstract

The objective of this study was to review the available information on the signaling proteins produced by adipose tissue in the context of their role in regulating reproductive processes, including ovarian and uterine function. It is well known that both obesity and excessive leanness are associated with reproductive dysfunction. Adipokines are cytokines predominately or exclusively expressed by adipose tissue that circulate and affect target tissues. Four known adipokines, adiponectin, visfatin/PBEF, omentin and vaspin, all increase tissue sensitivity to insulin, and are thus described as ‘beneficial’. There is strong support for a role for adiponectin in the function of the ovary and placenta. There is evidence for direct effects of this adipokine on the late stages of folliculogenesis, and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles. In addition, clinical and genomic studies associate hypoadiponectinemia with obesity-related reproductive disorders, including the polycystic ovarian syndrome. The roles for visfatin/PBEF, omentin and vaspin in reproduction remain to be established. The conclusion thus drawn is that the expression of insulin-sensitizing adipokines varies with adipose abundance. These adipokines have demonstrated both the potential effects on ovarian function and the possible effects on the formation of the placenta, acting through multiple mechanisms.

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References

  1. Pasquali R, Gambineri A, Pagotto U . The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG 2006; 113: 1148–1159.

    CAS  PubMed  Google Scholar 

  2. Essah PA, Nestler JE . Metabolic syndrome in women with polycystic ovary syndrome. Fertil Steril 2006; 86 (Suppl 1): S18–S19.

    PubMed  Google Scholar 

  3. Sartor BM, Dickey RP . Polycystic ovarian syndrome and the metabolic syndrome. Am J Med Sci 2005; 330: 336–342.

    PubMed  Google Scholar 

  4. Cervero A, Dominguez F, Horcajadas JA, Quinonero A, Pellicer A, Simon C . The role of the leptin in reproduction. Curr Opin Obstet Gynecol 2006; 18: 297–303.

    PubMed  Google Scholar 

  5. Henson MC, Castracane VD . Leptin in pregnancy: an update. Biol Reprod 2006; 74: 218–229.

    CAS  PubMed  Google Scholar 

  6. Fietta P . Focus on leptin, a pleiotropic hormone. Minerva Med 2005; 96: 65–75.

    CAS  PubMed  Google Scholar 

  7. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E et al. Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 2006; 254–255: 127–132.

    PubMed  Google Scholar 

  8. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17: 4–12.

    CAS  PubMed  Google Scholar 

  9. Tilg H, Moschen AR . Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772–783.

    CAS  PubMed  Google Scholar 

  10. Trujillo ME, Scherer PE . Adiponectin—journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005; 257: 167–175.

    Article  CAS  PubMed  Google Scholar 

  11. Beltowski J . Apelin and visfatin: unique ‘beneficial’ adipokines upregulated in obesity? Med Sci Monit 2006; 12: RA112–RA119.

    CAS  PubMed  Google Scholar 

  12. de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes 2007; 56: 1655–1661.

    CAS  PubMed  Google Scholar 

  13. Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 2005; 102: 10610–10615.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Cianflone KM, Sniderman AD, Walsh MJ, Vu HT, Gagnon J, Rodriguez MA . Purification and characterization of acylation stimulating protein. J Biol Chem 1989; 264: 426–430.

    CAS  PubMed  Google Scholar 

  15. Kersten S . Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2001; 2: 282–286.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Ahima RS, Qi Y, Singhal NS . Adipokines that link obesity and diabetes to the hypothalamus. Prog Brain Res 2006; 153: 155–174.

    CAS  PubMed  Google Scholar 

  17. Ruiz-Cortes ZT, Martel-Kennes Y, Gevry NY, Downey BR, Palin MF, Murphy BD . Biphasic effects of leptin in porcine granulosa cells. Biol Reprod 2003; 68: 789–796.

    CAS  PubMed  Google Scholar 

  18. Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H et al. The role of leptin during the development of mouse preimplantation embryos. Mol Cell Endocrinol 2003; 202: 185–189.

    CAS  PubMed  Google Scholar 

  19. Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C et al. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 2003; 88: 4823–4831.

    CAS  PubMed  Google Scholar 

  20. Baratta R, Amato S, Degano C, Farina MG, Patane G, Vigneri R et al. Adiponectin relationship with lipid metabolism is independent of body fat mass: evidence from both cross-sectional and intervention studies. J Clin Endocrinol Metab 2004; 89: 2665–2671.

    CAS  PubMed  Google Scholar 

  21. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426–430.

    Article  CAS  PubMed  Google Scholar 

  22. Stephens JM, Vidal-Puig AJ . An update on visfatin/pre-B cell colony-enhancing factor, a ubiquitously expressed, illusive cytokine that is regulated in obesity. Curr Opin Lipidol 2006; 17: 128–131.

    CAS  PubMed  Google Scholar 

  23. Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006; 290: E1253–E1261.

    CAS  PubMed  Google Scholar 

  24. Sekar N, Garmey JC, Veldhuis JD . Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells: joint amplification of pivotal sterol-regulatory genes encoding the low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory (stAR) protein and cytochrome P450 side-chain cleavage (P450scc) enzyme. Mol Cell Endocrinol 2000; 159: 25–35.

    CAS  PubMed  Google Scholar 

  25. Kadowaki T, Yamauchi T . Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439–451.

    CAS  PubMed  Google Scholar 

  26. Hug C, Lodish HF . The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol 2005; 5: 129–134.

    CAS  PubMed  Google Scholar 

  27. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K . Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 116: 1784–1792.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006; 8: 516–523.

    CAS  PubMed  Google Scholar 

  29. Hosch SE, Olefsky JM, Kim JJ . APPLied mechanics: uncovering how adiponectin modulates insulin action. Cell Metab 2006; 4: 5–6.

    CAS  PubMed  Google Scholar 

  30. Tortoriello DV, McMinn JE, Chua SC . Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL/6J mice. Int J Obes (London) 2007; 3: 395–402.

    Google Scholar 

  31. Matsuzawa Y . The metabolic syndrome and adipocytokines. FEBS Lett 2006; 580: 2917–2921.

    CAS  PubMed  Google Scholar 

  32. Berg AH, Combs TP, Scherer PE . ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002; 13: 84–89.

    CAS  PubMed  Google Scholar 

  33. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001; 86: 3815–3819.

    CAS  PubMed  Google Scholar 

  34. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004; 279: 1304–1309.

    CAS  PubMed  Google Scholar 

  35. Miyazaki T, Bub JD, Uzuki M, Iwamoto Y . Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun 2005; 333: 79–87.

    CAS  PubMed  Google Scholar 

  36. Onay-Besikci A, Altarejos JY, Lopaschuk GD . gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. J Biol Chem 2004; 279: 44320–44326.

    CAS  PubMed  Google Scholar 

  37. Johnson LW, Weinstock RS . The metabolic syndrome: concepts and controversy. Mayo Clin Proc 2006; 81: 1615–1620.

    CAS  PubMed  Google Scholar 

  38. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002; 8: 731–737.

    CAS  PubMed  Google Scholar 

  39. Lord E, Ledoux S, Murphy BD, Beaudry D, Palin MF . Expression of adiponectin and its receptors in swine. J Anim Sci 2005; 83: 565–578.

    CAS  PubMed  Google Scholar 

  40. Chabrolle C, Tosca L, Dupont J . Expression and regulation of adiponectin and its receptors (AdipoR1 and AdipoR2) in the rat ovary. Reproduction 2007; 133: 719–731.

    CAS  PubMed  Google Scholar 

  41. Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD . Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 2006; 147: 5178–5186.

    CAS  PubMed  Google Scholar 

  42. Bersinger NA, Birkhauser MH, Wunder DM . Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles. Gynecol Endocrinol 2006; 22: 479–483.

    CAS  PubMed  Google Scholar 

  43. Chabrolle C, Tosca L, Crochet S, Tesseraud S, Dupont J . Expression of adiponectin and its receptors (AdipoR1 and AdipoR2) in chicken ovary: potential role in ovarian steroidogenesis. Domest Anim Endocrinol 2007 (in press).

  44. Liu YH, Tsai EM, Chen YL, Chen HS, Chen YC, Wu LC et al. Serum adiponectin levels increase after human chorionic gonadotropin treatment during in vitro fertilization. Gynecol Obstet Invest 2006; 62: 61–65.

    CAS  PubMed  Google Scholar 

  45. Escobar-Morreale HF, Luque-Ramirez M, San Millan JL . The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocr Rev 2005; 26: 251–282.

    CAS  PubMed  Google Scholar 

  46. Carmina E, Orio F, Palomba S, Cascella T, Longo RA, Colao AM et al. Evidence for altered adipocyte function in polycystic ovary syndrome. Eur J Endocrinol 2005; 152: 389–394.

    CAS  PubMed  Google Scholar 

  47. Ardawi MS, Rouzi AA . Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. Fertil Steril 2005; 83: 1708–1716.

    CAS  PubMed  Google Scholar 

  48. Seftel AD . Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Urol 2005; 174: 1045–1046.

    PubMed  Google Scholar 

  49. Stewart DR, Dombroski BA, Urbanek M, Ankener W, Ewens KG, Wood JR et al. Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity. J Clin Endocrinol Metab 2006; 91: 4112–4117.

    CAS  PubMed  Google Scholar 

  50. Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P et al. Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 2006; 55: 523–529.

    CAS  PubMed  Google Scholar 

  51. Fredriksson J, Carlsson E, Orho-Melander M, Groop L, Ridderstrale M . A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects. Int J Obes (London) 2006; 30: 226–232.

    CAS  Google Scholar 

  52. Panidis D, Kourtis A, Kukuvitis A, Farmakiotis D, Xita N, Georgiou I et al. Association of the T45G polymorphism in exon 2 of the adiponectin gene with polycystic ovary syndrome: role of Delta4-androstenedione. Hum Reprod 2004; 19: 1728–1733.

    CAS  PubMed  Google Scholar 

  53. Haap M, Machicao F, Stefan N, Thamer C, Tschritter O, Schnuck F et al. Genetic determinants of insulin action in polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2005; 113: 275–281.

    CAS  PubMed  Google Scholar 

  54. Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T et al. Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinology 2006; 147: 3203–3210.

    CAS  PubMed  Google Scholar 

  55. Caminos JE, Nogueiras R, Gallego R, Bravo S, Tovar S, Garcia-Caballero T et al. Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab 2005; 90: 4276–4286.

    CAS  PubMed  Google Scholar 

  56. Chen J, Tan B, Karteris E, Zervou S, Digby J, Hillhouse EW et al. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia 2006; 49: 1292–1302.

    CAS  PubMed  Google Scholar 

  57. Lappas M, Yee K, Permezel M, Rice GE . Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J Endocrinol 2005; 186: 457–465.

    CAS  PubMed  Google Scholar 

  58. Lappas M, Permezel M, Rice GE . Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. Endocrinology 2005; 146: 3334–3342.

    CAS  PubMed  Google Scholar 

  59. Redman CW, Sargent IL . Latest advances in understanding preeclampsia. Science 2005; 308: 1592–1594.

    CAS  PubMed  Google Scholar 

  60. Ray JG, Diamond P, Singh G, Bell CM . Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG 2006; 113: 379–386.

    CAS  PubMed  Google Scholar 

  61. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M . Adiponectin gene haplotype is associated with preeclampsia. Genet Test 2006; 10: 35–39.

    CAS  PubMed  Google Scholar 

  62. Fuglsang J, Skjaerbaek C, Frystyk J, Flyvbjerg A, Ovesen P . A longitudinal study of serum adiponectin during normal pregnancy. BJOG 2006; 113: 110–113.

    CAS  PubMed  Google Scholar 

  63. Suwaki N, Masuyama H, Nakatsukasa H, Masumoto A, Sumida Y, Takamoto N et al. Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. Am J Obstet Gynecol 2006; 195: 1687–1692.

    CAS  PubMed  Google Scholar 

  64. Caja S, Torrente M, Martinez I, Abelenda M, Puerta M . Adiponectin values are unchanged during pregnancy in rats. J Endocrinol Invest 2005; 28: 609–615.

    CAS  PubMed  Google Scholar 

  65. D'Anna R, Baviera G, Corrado F, Giordano D, De Vivo A, Nicocia G et al. Adiponectin and insulin resistance in early- and late-onset pre-eclampsia. BJOG 2006; 113: 1264–1269.

    CAS  PubMed  Google Scholar 

  66. Mazaki-Tovi S, Kanety H, Sivan E . Adiponectin and human pregnancy. Curr Diab Rep 2005; 5: 278–281.

    CAS  PubMed  Google Scholar 

  67. Thyfault JP, Hedberg EM, Anchan RM, Thorne OP, Isler CM, Newton ER et al. Gestational diabetes is associated with depressed adiponectin levels. J Soc Gynecol Investig 2005; 12: 41–45.

    CAS  PubMed  Google Scholar 

  68. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000; 102: 1296–1301.

    CAS  PubMed  Google Scholar 

  69. Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S et al. Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 2005; 97: 1245–1252.

    CAS  PubMed  Google Scholar 

  70. Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K . Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem 2004; 279: 28670–28674.

    CAS  PubMed  Google Scholar 

  71. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002; 105: 2893–2898.

    CAS  PubMed  Google Scholar 

  72. Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res 2005; 309: 99–109.

    CAS  PubMed  Google Scholar 

  73. Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B et al. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 2004; 116: 445–456.

    CAS  PubMed  Google Scholar 

  74. Nechamen CA, Thomas RM, Dias JA . APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol 2007; 260–262: 93–99.

    PubMed  Google Scholar 

  75. Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS et al. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 2004; 279: 19431–19440.

    CAS  PubMed  Google Scholar 

  76. Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 2006; 281: 2654–2660.

    CAS  PubMed  Google Scholar 

  77. Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM et al. Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. Biochem Biophys Res Commun 2006; 345: 1414–1424.

    CAS  PubMed  Google Scholar 

  78. Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004; 145: 367–383.

    CAS  PubMed  Google Scholar 

  79. Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R . Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998; 338: 1876–1880.

    CAS  PubMed  Google Scholar 

  80. Pasquali R, Gambineri A, Biscotti D, Vicennati V, Gagliardi L, Colitta D et al. Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 2000; 85: 2767–2774.

    CAS  PubMed  Google Scholar 

  81. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I . Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994; 14: 1431–1437.

    CAS  PubMed  PubMed Central  Google Scholar 

  82. Trujillo ME, Scherer PE . Adipose tissue-derived factors: impact on health and disease. Endocr Rev 2006; 27: 762–778.

    CAS  PubMed  Google Scholar 

  83. Ognjanovic S, Bryant-Greenwood GD . Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. Am J Obstet Gynecol 2002; 187: 1051–1058.

    CAS  PubMed  Google Scholar 

  84. Kendal CE, Bryant-Greenwood GD . Pre-B-cell colony-enhancing factor (PBEF/visfatin) gene expression is modulated by NF-kappaB and AP-1 in human amniotic epithelial cells. Placenta 2007; 28: 305–314.

    CAS  PubMed  Google Scholar 

  85. Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91: 295–299.

    CAS  PubMed  Google Scholar 

  86. Tan BK, Chen J, Digby JE, Keay SD, Kennedy CR, Randeva HS . Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin. J Clin Endocrinol Metab 2006; 91: 5022–5028.

    CAS  PubMed  Google Scholar 

  87. Chan TF, Chen YL, Lee CH, Chou FH, Wu LC, Jong SB et al. Decreased plasma visfatin concentrations in women with gestational diabetes mellitus. J Soc Gynecol Investig 2006; 13: 364–367.

    CAS  PubMed  Google Scholar 

  88. Zhang YY, Gottardo L, Thompson R, Powers C, Nolan D, Duffy J et al. A visfatin promoter polymorphism is associated with low-grade inflammation and type 2 diabetes. Obesity (Silver Spring) 2006; 14: 2119–2126.

    CAS  Google Scholar 

  89. Bailey SD, Loredo-Osti JC, Lepage P, Faith J, Fontaine J, Desbiens KM et al. Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French–Canadian population. Diabetes 2006; 55: 2896–2902.

    CAS  PubMed  Google Scholar 

  90. Arner P . Visfatin—a true or false trail to type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91: 28–30.

    CAS  PubMed  Google Scholar 

  91. Komiya T, Tanigawa Y, Hirohashi S . Cloning of the novel gene intelectin, which is expressed in intestinal Paneth cells in mice. Biochem Biophys Res Commun 1998; 251: 759–762.

    CAS  PubMed  Google Scholar 

  92. Schaffler A, Neumeier M, Herfarth H, Furst A, Scholmerich J, Buchler C . Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 2005; 1732: 96–102.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculté de médecine vétérinaire, Centre de recherche en reproduction animale, Université de Montréal, Québec, Canada

    D B Campos & B D Murphy

  2. Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Sao Paolo, Brasil

    D B Campos

  3. Dairy and Swine Research and Development Center, Agriculture and Agri-Food Canada, Lennoxville, Québec, Canada

    M-F Palin

  4. Department of Animal Science, McGill University, Québec, Canada

    V Bordignon

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  1. D B Campos
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Campos, D., Palin, MF., Bordignon, V. et al. The ‘beneficial’ adipokines in reproduction and fertility. Int J Obes 32, 223–231 (2008). https://doi.org/10.1038/sj.ijo.0803719

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