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Vaccination of chronic myeloid leukemia patients with autologous in vitro cultured leukemic dendritic cells

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References

  1. Clift RA, Appelbaum FR, Thomas ED: Treatment of chronic myeloid leukemia by marrow transplantation. Blood 1993; 82: 1954–1956.

    CAS  PubMed  Google Scholar 

  2. Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Bone Marrow Transplantation Working Party Chronic Leukemia. Blood 1995; 86: 2041–2050.

    CAS  PubMed  Google Scholar 

  3. Coleman S, Throp D, Fisher J, Bailey-Wood R, Lim SH . Cytokine enhancement of immunogenecity in chronic myeloid leukemia. Leukemia 1997; 11: 2055–2059.

    Article  CAS  PubMed  Google Scholar 

  4. Clark RE, Dody IA, Hill SC, Lill JR, Aubert G, Macintyre AR et al. Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood 2001; 98: 2887–2893.

    Article  CAS  PubMed  Google Scholar 

  5. Cella M, Sallusto F, Lanzavecchia A . Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997; 9: 10–16.

    Article  CAS  PubMed  Google Scholar 

  6. Choudhury A, Gajewski JL, Liang JC, Popat U, Claxton DF, Kliche K-O et al. Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against philadelphia chromosome-positive chronic myelogenous leukemia. Blood 1997; 89: 1133–1142.

    CAS  PubMed  Google Scholar 

  7. Vermorken JB, Claessen AME, van Tinteren H, Gall HE, Ezinga R, Meijer S et al. Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. Lancet 1999; 353: 345–350.

    Article  CAS  PubMed  Google Scholar 

  8. Vuylsteke R JCLM, van Leeuwen PAM, Meijer S, Wijnands PG, Statius Muller MG, Bus DH et al. A novel method of sampling tumor draining lymph nodes for phenotypic and functional analysis of dendritic cells and T-cells. Am J Pathol 2002; 61: 19–26.

    Article  Google Scholar 

  9. de Gruijl TD, Bontkes HJ, Walboomers JMM, Stukart MJ, Robbesom AA, vonBlomberg-van der Flier BM et al. Analysis of IgG reactivity against human papillomavirus type-16 E7 in patients with cervical intraepithelial neoplasia indicates an association with clearance of viral infection: results of a prospective study. Int J Cancer 1996; 731: 731–738.

    Article  Google Scholar 

  10. Druker BJ, Talpaz M, Resta D, Resta DJ, Peng B, Buchdunger E et al. Activity and safety of a specific inhibitor of the BCR-ABL tyrosine-kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1038–1042.

    Article  CAS  PubMed  Google Scholar 

  11. Weisberg E, Griffin JD . Mechanism of resistance to the ABL tyrosine-kinase inhibitor STI571 in BCR-ABL transformed hematopoietic cell lines. Blood 2000; 95: 3498–3505.

    CAS  PubMed  Google Scholar 

  12. Tipping AJ, Mahon FX, Zafirides G, Lagarde V, Goldman JM, Melo JV . Drug responses of imatinib mesylate-resistant cells: synergism of imatinib with other chemotherapeutic drugs. Leukemia 2002; 16: 2349–2357.

    Article  CAS  PubMed  Google Scholar 

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Ossenkoppele, G., Stam, A., Westers, T. et al. Vaccination of chronic myeloid leukemia patients with autologous in vitro cultured leukemic dendritic cells. Leukemia 17, 1424–1426 (2003). https://doi.org/10.1038/sj.leu.2402979

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