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T Neoplasias

Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

Leukemia volume 20, pages 313–318 (2006)Cite this article

Abstract

Among peripheral T-cell lymphomas (PTCL), the heterogeneous category of unspecified PTCL represents the most common subtype. Nevertheless, recurrent chromosomal translocations are unknown in this aggressive type of lymphoma. Here we describe a novel t(5;9)(q33;q22) in unspecified PTCL. Molecular analyses delineated the breakpoints to ITK and SYK resulting in a previously undescribed expression of the Syk tyrosine kinase by Itk. ITK–SYK transcripts were detected in five of 30 (17%) unspecified PTCL, but not in cases of angioimmunoblastic T-cell lymphoma (n=9) and anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma (n=7). In all five translocation-positive cases, the breakpoints were identical fusing the N-terminal pleckstrin homology domain and proline-rich region of ITK to the tyrosine kinase domain of SYK. Three of the five t(5;9)(q33;q22)+ unspecified PTCL shared a very similar histological pattern with predominant involvement of lymphoid follicles and the same CD3+CD5+CD4+bcl-6+CD10+ immunophenotype. These results demonstrate the presence of a recurrent t(5;9)(q33;q22) in a subset of unspecified PTCL, which may represent a novel distinct subgroup of PTCL.

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Authors and Affiliations

  1. Department of Pathology, Medical University of Vienna, Vienna, Austria

    B Streubel & A Chott

  2. Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria

    U Vinatzer

  3. Department of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria

    M Willheim

  4. Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria

    M Raderer

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  1. B Streubel
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  2. U Vinatzer
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  3. M Willheim
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  4. M Raderer
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  5. A Chott
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Correspondence to B Streubel.

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Streubel, B., Vinatzer, U., Willheim, M. et al. Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Leukemia 20, 313–318 (2006). https://doi.org/10.1038/sj.leu.2404045

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