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Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Oncogene volume 18, pages 1205–1208 (1999)Cite this article

Abstract

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

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Acknowledgements

This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

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Authors and Affiliations

  1. Department of Surgery, Divison of Urology, University of Kentucky, Lexington, Kentucky, USA

    Jason Cook, Sumathi Krishnan, Stephen F Sells & Vivek M Rangnekar

  2. Department of Surgery, Divison of Pathology, University of Kentucky, Lexington, Kentucky, USA

    Michael H Weinstein

  3. Department of Surgery, Divison of Microbiology & Immunology, University of Kentucky, Lexington, Kentucky, USA

    Vivek M Rangnekar

  4. Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA

    Vivek M Rangnekar

  5. Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Subbian Ananth & Vikas P Sukhatme

  6. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Vikas P Sukhatme

  7. Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA

    Yang Shi

  8. Urologic Oncology Section, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA

    McClellan M Walther & W Marston Linehan

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  1. Jason Cook
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Cook, J., Krishnan, S., Ananth, S. et al. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene 18, 1205–1208 (1999). https://doi.org/10.1038/sj.onc.1202416

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