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  • Oncogenomics
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Frequent mutations of Fas gene in nasal NK/T cell lymphoma

Oncogene volume 21, pages 4702–4705 (2002)Cite this article

Abstract

Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling through binding of Fas ligand. Mutation of Fas gene in lymphoid cells results in accumulation of these cells, which might thus contribute to lymphomagenesis. We examined the open reading frame of Fas cDNA in 14 cases of nasal NK/T-cell lymphoma. Mutations of Fas gene were detected in seven (50%) of 14 cases which comprised four frameshift, two missense, and one silent mutations. Frameshift mutations were caused by insertion of 1 bp (A) at nucleotide 1095 in two cases and by deletion of 1 bp at nucleotide 597 and at 704, respectively, in one each. Mouse T-cell lymphoma cells transfected with two missense mutated genes and frameshift mutations caused by insertion of 1 bp (A) at nucleotide 1095 were resistant to apoptosis induced by the anti-Fas antibody. These findings suggested that accumulation of lymphoid cells with Fas mutations provides a basis for the development of nasal NK/T-cell lymphoma.

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Authors and Affiliations

  1. Department of Pathology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan

    Tetsuya Takakuwa, Zhiming Dong, Shinichi Nakatsuka & Katsuyuki Aozasa

  2. Department of Otorhinolaryngology, University of Ryukyus, Faculty of Medicine, Okinawa, 903-0215, Japan

    Shizuo Kojya

  3. Department of Otorhinolaryngology, Asahikawa Medical College, Asahikawa, 078-8510, Japan

    Yasuaki Harabuchi

  4. Department of Genetics, Osaka University, Graduate School of Medicine, Osaka, 565-0871, Japan

    Shigekazu Nagata

  5. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea

    Woo-Ick Yang

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  1. Tetsuya Takakuwa
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  2. Zhiming Dong
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  3. Shinichi Nakatsuka
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  5. Yasuaki Harabuchi
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  8. Katsuyuki Aozasa
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Correspondence to Katsuyuki Aozasa.

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Takakuwa, T., Dong, Z., Nakatsuka, S. et al. Frequent mutations of Fas gene in nasal NK/T cell lymphoma. Oncogene 21, 4702–4705 (2002). https://doi.org/10.1038/sj.onc.1205571

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