Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Oncogenomics
  • Published:

High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas

Oncogene volume 21, pages 6689–6693 (2002)Cite this article

Abstract

To clarify the significance of p53 mutations in liver metastasis of colorectal carcinogenesis, the characteristics of p53 mutations from 51 liver metastases and 76 primary invasive carcinomas without liver metastasis (Dukes' A, B and C) were compared. The frequency of tumors with p53 mutations was 61% (31 out of 51) in the liver metastases, and 51% (39 out of 76) in the primary carcinomas without liver metastasis. Approximately 90% of the informative cases having p53 mutation showed 17pLOH. Mutations detected within exons 4–10 of the p53 gene included missense, nonsense, frameshift, inframe deletion, and inframe insertion mutations. Out of the tumors with p53 mutations, we found that the percentage of tumors with protein-truncating mutations (nonsense and frameshift mutations) was extremely higher in liver metastases (16 out of 31, 52%) than in primary carcinomas without liver metastasis (5 out of 39, 13%) (P=0.0005). The present results suggest that protein-truncating mutations of the p53 gene are more relevant than missense mutations as one of the prognostic factors in liver metastasis of colorectal carcinomas.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  • Auvinen A, Isola J, Visakorpi T, Koivula T, Virtanen S, Hakama M . 1994 Br. J. Cancer 70: 293–296

  • Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, Taylor GR, Dixon MF, Quirke P . 1993 Gastroenterology 104: 57–64

  • Clore GM, Omichinski JG, Sakaguchi K, Zambrano N, Sakamoto H, Appella E, Gronenborn AM . 1994 Science 265: 386–391

  • Fukasawa K, Choi T, Kuriyama R, Roulong A, VandeWoude GF . 1996 Science 271: 1744–1747

  • Goh H-S, Yao J, Smith DR . 1995 Cancer Res. 55: 5217–5221

  • Hamelin R, Laurent-Puig P, Olschwang S, Jego N, Asselain B, Remvikos Y, Girodet J, Salmon RJ, Thomas G . 1994 Gastroenterology 106: 42–48

  • Harris CC, Hollstein M . 1993 New Engl. J. Med. 329: 1318–1327

  • Hartmann A, Blaszyk H, McGovern RM, Schroeder JJ, Cunningham J, De Vries EMG, Kovach JS, Sommer SS . 1995 Oncogene 10: 681–688

  • Kemp CL, Donehower LA, Bradley A, Balmain A . 1993 Cell 74: 813–822

  • Kikuchi-Yanoshita R, Konishi M, Ito S, Seki M, Tanaka K, Maeda Y, Iino H, Fukayama M, Koike M, Mori T, Sakuraba H, Fukunari H, Iwama T, Miyaki M . 1992 Cancer Res. 52: 3965–3971

  • Lanza Jr G, Maestri I, Dubini A, Gafa R, Santini A, Ferretti S, Cavazzini L . 1996 Am. J. Clin. Pathol 105: 604–612

  • Lim BHG, Soong R, Grieu F, Robbins PD, House A, Iacopetta BJ . 1996 Int. J. Cancer 69: 200–204

  • May P, May E . 1999 Oncogene 18: 7621–7636

  • Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M, Maeda y, Iwama T, Mishima Y, Mori T, Koike M . 1994 Cancer Res. 54: 3011–3020

  • Morrin M, Kelly M, Barrett N, Delaney P . 1994 Gut 35: 1627–1631

  • Mulder JWR, Baas IO, Polak MM, Goodman SN, Offerhaus GJA . 1995 Br. J. Cancer 71: 1257–1262

  • Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FC, Weston A, Modali R, Harris CC, Vogelstein B . 1989 Nature 342: 705–708

  • Pavletich NP, Chambers KA, Pabo CO . 1993 Genes Dev. 7: 2556–2564

  • Saitoh S, Cunningham J, De Vries EMG, McGovern RM, Schroeder JJ, Hartmann A, Blaszyk H, Wold LE, Schaid D, Sommer SS, Kovach JS . 1994 Oncogene 9: 2869–2875

  • Shaulsky G, Goldfinger N, Ben-Ze'ev A, Rotter V . 1990 Mol. Cell Biol. 10: 6565–6577

  • Smith DR, Ji C-Y, Goh H-S . 1996 Br. J. Cancer 74: 216–223

  • Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JHJ, Harris CC . 1996 Genes Dev. 10: 1219–1232

Download references

Author information

Authors and Affiliations

  1. Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, 113-8677, Japan

    Michiko Miyaki, Takeru Iijima & Yumi Kita

  2. Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, 113-8677, Japan

    Masamichi Yasuno & Takeo Mori

  3. Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, 113-8677, Japan

    Tsunekazu Hishima

  4. Institute of Molecular Oncology, Showa University, Tokyo, 142-8666, Japan

    Michiko Miyaki, Takeru Iijima & Toshio Kuroki

Authors
  1. Michiko Miyaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeru Iijima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masamichi Yasuno
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yumi Kita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tsunekazu Hishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Toshio Kuroki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takeo Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michiko Miyaki.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miyaki, M., Iijima, T., Yasuno, M. et al. High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas. Oncogene 21, 6689–6693 (2002). https://doi.org/10.1038/sj.onc.1205887

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1205887

Keywords

This article is cited by

Search

Advanced search

Quick links