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eIF4E – from translation to transformation

Oncogene volume 23, pages 3172–3179 (2004)Cite this article

Abstract

Over the years, studies have focused on the transcriptional regulation of oncogenesis. More recently, a growing emphasis has been placed on translational control. The Ras and Akt signal transduction pathways play a critical role in regulating mRNA translation and cellular transformation. The question arises: How might the Ras and Akt signaling pathways affect translation and mediate transformation? These pathways converge on a crucial effector of translation, the initiation factor eIF4E, which binds the 5′cap of mRNAs. This review focuses on the role of eIF4E in oncogenesis. eIF4E controls the translation of various malignancy-associated mRNAs which are involved in polyamine synthesis, cell cycle progression, activation of proto-oncogenes, angiogenesis, autocrine growth stimulation, cell survival, invasion and communication with the extracellular environment. eIF4E-mediated translational modulation of these mRNAs plays a pivotal role in both tumor formation and metastasis. Interestingly, eIF4E activity is implicated in mitosis, embryogenesis and in apoptosis. Finally, the finding that eIF4E is overexpressed in several human cancers makes it a prime target for anticancer therapies.

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Acknowledgements

We thank Colin Lister, Meena Viparti and Pamela Kirk for their help. This research was supported by grants from the National Cancer Institute and Canadian Institutes of Health Research of Canada. YM is a recipient of a NCIC fellowship. EP is supported by an award to NS from CaP Cure. LR is a recipient of a CIHR fellowship. KY is supported by a NCIC operating grant to NS. LWL is supported by a CIHR operating grant to NS. NS is a James McGill Professor and Howard Hughes International Scholar.

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  1. Department of Biochemistry, McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montreal, Quebec, Canada, H3G 1Y6

    Yaël Mamane, Emmanuel Petroulakis, Liwei Rong, Kaori Yoshida, Lian Wee Ler & Nahum Sonenberg

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Mamane, Y., Petroulakis, E., Rong, L. et al. eIF4E – from translation to transformation. Oncogene 23, 3172–3179 (2004). https://doi.org/10.1038/sj.onc.1207549

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