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The interplay between Src and integrins in normal and tumor biology

Oncogene volume 23, pages 7928–7946 (2004)Cite this article

Abstract

Src family nonreceptor protein tyrosine kinases transduce signals that control normal cellular processes such as cell proliferation, adhesion and motility. Normally, cellular Src is held in an inactive state, but in several cancer types, abnormal events lead to elevated kinase activity of the protein and cause pleiotropic cellular responses inducing transformation and metastasis. A prerequisite of the ability of a cancer cell to undergo metastasis into distant tissues is to penetrate surrounding extracellular matrices. These processes are facilitated by the integrin family of cell adhesion molecules. As is the case with Src, altered integrin activity or substrate affinity can contribute to the neoplastic phenotype. Therefore, understanding the interplay between Src and integrin function has been of intense interest over the past few years. This review focuses on the role of Src and integrin signaling in normal cells and how this is deregulated in human cancer. We will identify the key players in the integrin-mediated signaling pathways involved in cell motility and apoptosis, such as FAK, paxillin and p130CAS, and discuss how Src signaling affects the formation of focal adhesions and the extracellular matrix.

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Acknowledgements

We thank Danielle Scheswohl for critically reading the manuscript and Jessica Harrell for assistance with its preparation. This work was supported by grants from the National Institutes of Health (CA90901 and HL45100) (MDS).

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  1. Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 27599, NC, USA

    Martin P Playford & Michael D Schaller

  2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, NC, USA

    Michael D Schaller

  3. Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, 27599, NC, USA

    Michael D Schaller

  4. Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, 27599, NC, USA

    Michael D Schaller

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Playford, M., Schaller, M. The interplay between Src and integrins in normal and tumor biology. Oncogene 23, 7928–7946 (2004). https://doi.org/10.1038/sj.onc.1208080

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