Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance

Kirsten H. Chalmers; Mauro Botta; David Parker

doi:10.1039/C0DT01232G

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Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for ¹⁹F magnetic resonance†

Kirsten H. Chalmers,^a Mauro Botta^b and David Parker*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@durham.ac.uk

^b Dipartimento di Scienze dell' Ambiente e della Vita, Università del Piemonte Orientale ‘Amedeo Avogadro’, Viale Teresa Michel II, Alessandria, Italy

Abstract

The synthesis and ¹⁹F NMR spectroscopic properties are reported for three series of CF₃-labelled lanthanide(III) complexes, based on mono- and diamide cyclen ligands. Analyses of variable temperature, pH and field ¹⁹F, ¹⁷O and ¹H NMR spectroscopic experiments are reported and the merits of a triphosphinate mono-amide complex defined by virtue of its favourable isomer distribution and attractive relaxation properties. These lead to an enhanced sensitivity of detection in ¹⁹F magnetic resonance experiments versus a diamagnetic Y(III) analogue, paving the way for future shift and imaging studies.

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Supplementary files

Additional information on the variation of the relaxivity of two Gadolinium complexes PDF (298K)

Article information

DOI: https://doi.org/10.1039/C0DT01232G
Article type: Paper
Submitted: 14 Sep 2010
Accepted: 08 Nov 2010
First published: 03 Dec 2010

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Dalton Trans., 2011,40, 904-913

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Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for ¹⁹F magnetic resonance

K. H. Chalmers, M. Botta and D. Parker, Dalton Trans., 2011, 40, 904 DOI: 10.1039/C0DT01232G

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Dalton Transactions