Issue 8, 2017

Current detection technologies for circulating tumor cells

Abstract

Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for early diagnosis of cancers, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs. Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we classify the currently reported CTC detection technologies, introduce some representative samples for each technology, conclude the advantages and limitations, and give a future perspective including the challenges and opportunities of CTC detection.

Graphical abstract: Current detection technologies for circulating tumor cells

Supplementary files

Article information

Article type
Tutorial Review
Submitted
08 Nov 2016
First published
10 Apr 2017

Chem. Soc. Rev., 2017,46, 2038-2056

Current detection technologies for circulating tumor cells

Z. Shen, A. Wu and X. Chen, Chem. Soc. Rev., 2017, 46, 2038 DOI: 10.1039/C6CS00803H

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