Issue 9, 2018
From the journal:

Analyst

Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers†

J. W. Lowdon,a   S. M. O. Alkirkit,a   R. E. Mewis, ORCID logo a   D. Fulton,b   C. E. Banks, ORCID logo c   O. B. Sutcliffe ORCID logo ‡*ad  and  M. Peeters ORCID logo ‡*a  

* Corresponding authors

a Manchester Metropolitan University, Faculty of Science and Engineering, School of Science and the Environment, Division of Chemistry and Environmental Science, Chester Street, Manchester M1 5GD, UK
E-mail: o.sutcliffe@mmu.ac.uk, m.peeters@mmu.ac.uk
Tel: +44 (0)161 247 1450

b Newcastle University, School of Chemistry, Bedson Building, Newcastle Upon Tyne, UK

c Manchester Metropolitan University, Faculty of Science and Engineering, School of Healthcare Science, Chester Street, Manchester M1 5GD, UK

d MANchester DRug Analysis and Knowledge Exchange (MANDRAKE), Manchester Metropolitan University, Faculty of Science and Engineering, Chester Street, Manchester M1 5GD, UK

Abstract

In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.

Graphical abstract: Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

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Article information

DOI
https://doi.org/10.1039/C8AN00131F
Article type
Communication
Submitted
23 Jan 2018
Accepted
11 Apr 2018
First published
12 Apr 2018
This article is Open Access
Creative Commons BY-NC license

Analyst, 2018,143, 2002-2007

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Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

J. W. Lowdon, S. M. O. Alkirkit, R. E. Mewis, D. Fulton, C. E. Banks, O. B. Sutcliffe and M. Peeters, Analyst, 2018, 143, 2002 DOI: 10.1039/C8AN00131F

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