Issue 7, 2011

Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX

Abstract

We applied Systematic Evolution of Ligands by EXponential enrichment using Small Cell Lung Cancer (SCLC) cells. A DNA aptamer was identified and evaluated by fluorescent confocal microscopy and flow cytometry. Our results showed that the DNA aptamer binds to molecules that exist predominantly on target SCLC cell surfaces compared with other types of SCLC cells.

Graphical abstract: Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec 2010
Accepted
01 Feb 2011
First published
14 Feb 2011

Analyst, 2011,136, 1310-1312

Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX

T. Kunii, S. Ogura, M. Mie and E. Kobatake, Analyst, 2011, 136, 1310 DOI: 10.1039/C0AN00962H

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