Issue 3, 2010
From the journal:

Food & Function

Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats

Haydé Azeneth Vergara-Castañeda,a   Ramón Gerardo Guevara-González,b   Minerva Ramos-Gómez,a   Rosalía Reynoso-Camacho,a   Horacio Guzmán-Maldonado,c   Ana Angélica Feregrino-Pérez,a   B. Dave Oomahd  and  Guadalupe Loarca-Piña*a  

* Corresponding authors

a Programa de Posgrado en Alimentos del Centro de la República (PROPAC), Research and Graduate Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Querétaro, Qro, México
E-mail: loarca@uaq.mx
Fax: +52 (442) 192-1307
Tel: +52 442 192 1307

b School of Engineering, Universidad Autónoma de Querétaro, Querétaro, Qro, México

c Biotechnology and Legume Laboratories, Experimental Station El Bajío, National Research Institute for Forestry, Agriculture and Livestock (INIFAP), Celaya, Mexico

d National Bioproducts and Bioprocesses Program, Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Summerland, British Columbia, Canada

Abstract

The non-digestible fraction (NDF) of common bean (Phaseolus vulgaris L.) cultivar Bayo Madero was evaluated for its chemopreventive effect on azoxymethane (AOM) induced aberrant crypt foci (ACF) in rats. Diets containing cooked beans (CB) or its non-digestible fraction (NDF) were fed to 72 male rats after 2 azoxymethane injections (15 mg kg−1 of body weight once a week for 2 weeks). ACF number, short chain fatty acids (SCFA) and β-glucuronidase activity were measured in colon sections from rats sacrificed 7 weeks after the last AOM injection. Food intake and weight gain of rats were unaffected by CB and NDF. CB and NDF suppressed the AOM-induced formation of ACF (0.8 and 1.5 ACF/distal zone, respectively vs. 6.6 ACF/distal zone based on methylene blue stain) and lowered β-glucuronidase activity in cecal, colonic and fecal content compared to AOM group. SCFA production was not significantly different among fecal, cecal and colonic content. These results indicate that CB and NDF from Bayo Madero provide direct chemoprotection against early stage of azoxymethane (AOM)-induced colon cancer in rats.

Graphical abstract: Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats

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Article information

DOI
https://doi.org/10.1039/C0FO00130A
Article type
Paper
Submitted
31 Aug 2010
Accepted
25 Oct 2010
First published
08 Nov 2010

Food Funct., 2010,1, 294-300

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Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats

H. A. Vergara-Castañeda, R. G. Guevara-González, M. Ramos-Gómez, R. Reynoso-Camacho, H. Guzmán-Maldonado, A. A. Feregrino-Pérez, B. D. Oomah and G. Loarca-Piña, Food Funct., 2010, 1, 294 DOI: 10.1039/C0FO00130A

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