Issue 24, 2013
From the journal:

Journal of Materials Chemistry B

Structural role of zinc in biodegradation of alkali-free bioactive glasses

Ashutosh Goel,*a   Saurabh Kapoor,b   Antonio Tilocca,c   Raghu R. Rajagopalb  and  José M. F. Ferreirab  

* Corresponding authors

a Sterlite Technologies Ltd., E-1, E-2, E-3, MIDC Waluj, Aurangabad, India
E-mail: ashutosh.goel@sterlite.com
Tel: +91 7709621100

b Department of Materials and Ceramics Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal

c Department of Chemistry and Thomas Young Centre for Theory and Simulations of Materials, University College London, 20 Gordon Street, London WC1H 0AJ, UK

Abstract

We report on the effect of varying the Zn2+/Mg2+ ratio on the structure and biodegradation of glasses in an alkali-free system designed in the glass forming region of diopside (CaMgSi2O6)–fluorapatite [Ca5(PO4)3F]–TCP (3CaO·P2O5). The zinc-containing glasses designed in the as-mentioned ternary system are potential materials for their application in bone regeneration and tissue engineering. The melt-quenched glasses with compositions (mol%), 36.07CaO − (19.24 − x) MgO − xZnO − 5.61P2O5 − 38.49SiO2 − 0.59CaF2, where x varies between 0 and 10, have been investigated for their structure by molecular dynamics simulations as well as by nuclear magnetic resonance spectroscopy. In all the investigated glasses silicate and phosphate components are mainly present as Q2 (Si) and Q0 (orthophosphate) species, respectively. Zinc retains structural features similar to magnesium, with predominant five-fold coordination. The apatite-forming ability of glasses has been investigated by X-ray diffraction and infrared spectroscopy after immersion of glass powders in simulated body fluids for time durations varying between 1 h and 7 days, while their chemical degradation has been studied in Tris–HCl in accordance with ISO-10993-14. The increasing Zn2+/Mg2+ ratio decreases the chemical degradation of glasses as well as reducing their apatite forming ability. The results allowed us to discuss the biodegradation of alkali-free bioactive glasses on the basis of the structural role of zinc and magnesium.

Graphical abstract: Structural role of zinc in biodegradation of alkali-free bioactive glasses

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Article information

DOI
https://doi.org/10.1039/C3TB20163E
Article type
Paper
Submitted
03 Feb 2013
Accepted
26 Apr 2013
First published
17 May 2013

J. Mater. Chem. B, 2013,1, 3073-3082

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Structural role of zinc in biodegradation of alkali-free bioactive glasses

A. Goel, S. Kapoor, A. Tilocca, R. R. Rajagopal and J. M. F. Ferreira, J. Mater. Chem. B, 2013, 1, 3073 DOI: 10.1039/C3TB20163E

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