Original ContributionsAdenosquamous carcinoma of the upper aerodigestive tract: A clinicopathologic study of 12 cases and review of the literature
Section snippets
Materials and methods
Twelve cases of adenosquamous carcinoma occurring in the upper aerodigestive tract with adequate clinical information and available microscopic slides and paraffin tissue blocks were identified in the anatomic pathology files of Presbyterian Hospital of the University of Pittsburgh Medical Center. These cases were accessioned during the period 1983-2001.
Clinical data, including age at diagnosis, sex, race, location of the tumor, symptoms and duration, history of smoking and alcohol consumption,
Clinical
Clinical data pertaining to all 12 cases are shown in Table 1.Case Location Sex/Race Age Symptoms and Duration Smoking Alcohol Size (cm) Stage 1 Larynx (Supraglottic) F/W 64 Hoarseness, dysphagia, sore-throat, hemoptysis, 12 mo >100 pkyr N/A 4.5 T3 N0 M0 2 Larynx (Supraglottic) M/W 72 Neck mass, 3.5 mo 12 cigars/d × 52 yr Heavy, quit 7 yr 3.0 T2 N2c M0 3 Larynx (Transglottic) M/W 56 Hoarseness, 3 mo 90-135 pkyr Heavy 3.0
Review of the literature
A review of the English literature revealed at least 46 cases of histologically acceptable adenosquamous carcinoma of the upper aerodigestive tract with sufficient clinical information for further analysis.1, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18, 19, 20, 21, 22, 23 Additional cases have been reported but were excluded for lack of data pertaining to individual patients.6, 24
The clinical features of these 46 cases plus the 12 included in this report (total 58 cases) are summarized in
Discussion
Our study and review of the literature confirms that adenosquamous carcinoma (ASC) of the upper aerodigestive tract, as defined above, is an uncommon, aggressive neoplasm. It occurs over a broad age range (34 to 81 years) and is 2 to 4 times more common in men. The larynx is the most common site of origin, accounting for 44.8% of all cases, followed by the oral cavity (Table 4). In the larynx, the supraglottis is the preferred site, and in the oral cavity the floor of the mouth and tongue are
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