Basic–Alimentary TractPeroxisome proliferator-activated receptor γ ligands suppress colon carcinogenesis induced by azoxymethane in mice☆
References (0)
Cited by (180)
Common targets for a deadly duo of diabetes mellitus and colon cancer: Catching two fish with one worm
2021, European Journal of PharmacologyDrug rechanneling: A novel paradigm for cancer treatment
2021, Seminars in Cancer BiologyCitation Excerpt :Cancer cells overexpress PPARγ and play a significant role in the anti-apoptotic properties of cancer cells [134,135]. A growing scientific evidence suggests that inhibition of PPAR γ in cancer cells can inhibit proliferation and induce apoptosis in several cancer cell lines [136–139]. TZD repurposing for the treatment of several cancer types has been well studied and significant data has been published regarding its anti-proliferative and anti-neoplastic ability.
PPARγ agonist efatutazone and gefitinib synergistically inhibit the proliferation of EGFR-TKI-resistant lung adenocarcinoma cells via the PPARγ/PTEN/Akt pathway
2017, Experimental Cell ResearchCitation Excerpt :Exogenous ligands include troglitazone and efatutazone. Troglitazone, the first-generation thiazolidinedione (PPARγ ligands), has been demonstrated by numerous studies that ligands for PPARγ show prominent anti-proliferative effects in colorectal cancer [12], breast carcinoma [13], and hepatocellular cancer [14]. PPARγ protein regulates or interacts with a great deal of signal channels, such as PTEN pathway [15] which represses the activation of downstream targets and cell cycle associated proteins p21Cip1 [16] and p27 [14].
Development of Small Molecules Targeting the Wnt Signaling Pathway in Cancer Stem Cells for the Treatment of Colorectal Cancer
2015, Clinical Colorectal CancerCitation Excerpt :Recent studies have suggested that PPARγ has an inhibitory effect on cancer cell growth.159-161 It was also reported that PPARγ ligands suppressed colonic epithelial cell turnover and colon carcinogenesis by inhibiting the β-catenin/Tcf pathway,162 and PPARγ ligands might be potential chemopreventive agents for CRC.163,164 CRC is therefore a potentially preventable malignancy.165,166
Delineating the role of nuclear receptors in colorectal cancer, a focused review
2024, Discover OncologyUnderstanding the Role of Adipocytes and Fibroblasts in Cancer
2023, Annals of Plastic Surgery
- ☆
Supported in part by the priority research grant from Yokohama City University (to A.N.), a grant (SH44211) from the Human Science foundation (to A.N.), and a grant (Tokuteiryouiki C13204072, to A.N.) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.