Original investigation: transplantationHigh cumulative incidence of urinary tract transitional cell carcinoma after kidney transplantation in Taiwan
Section snippets
Methods
We retrospectively reviewed the records of 730 KT recipients (432 men, 298 women) who underwent follow-up at Taichung Veterans General Hospital in central Taiwan from February 1983 to December 2003. The occurrence and pattern of malignancies were assessed. The regimen of induction therapy was methylprednisolone, with or without CD25 antagonists (daclizumab [Zenapax; Hoffman-La Roche Inc, Basel, Switzerland] or basiliximab [Simulect; Novartis Pharma AG, Stein, Switerland]). Any new rejection
Results
In total, 730 KT recipients were followed up in our clinic (cumulative period of observation, 4,333 patients-years). The mean follow-up duration was 72.2 ± 54.4 months. The first year and fifth graft survival rates were 90.8% and 72.4%, respectively. The first year and fifth patient survival rates were 93.7% and 83.5%, respectively. Of them, 122 (16.7%) patients died with function grafts, 137 (18.8%) patients returned to dialysis, and another 14 patients were lost to follow-up for unknown
Discussion
Several large studies have reported that the prevalence of cancer in renal transplant recipients ranges from 4% to 18%, with an average of 6%.1, 2, 3, 4 The overall prevalence of cancer in the current series was similar to that of previous reports. Surprisingly, we found an unusually high prevalence of TCC (4.1%) among 730 renal transplant recipients, and TCC was the most common type (43.5%) of posttransplant malignancy in our series. Compared with other neoplasm, it was a significant excess
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