Original InvestigationPathogenesis and Treatment of Kidney DiseaseRevised Equations for Estimated GFR From Serum Creatinine in Japan
Section snippets
Inclusion and Exclusion Criteria
Inclusion criteria were: (1) age 18 years and older; (2) relatively stable kidney function, assessed by using SCr level; and (3) patient's agreement to have urinary Cin measured using a continuous infusion.
Exclusion criteria were: (1) acute kidney injury, (2) apparent malignancy, (3) problems in micturition, (4) pregnancy, (5) inulin allergy, (6) amputation, and (7) individuals for whom the investigator judged that measuring Cin was inappropriate. Although some study participants were
Patient Characteristics in the Development and Validation Populations
Characteristics of the development population (n = 413) and validation population (n = 350) are listed in Table 1. Distributions of participant numbers by cause of kidney disease and mean age, SCr level, albumin level, SUN level, height, weight, and body surface area were similar between the 2 populations. Mean Cin was also similar between them at 59.1 ± 35.4 mL/min/1.73 m2 in the development population and 57.2 ± 34.7 mL/min/1.73 m2 in the validation population. Proportions of participants
Discussion
We previously reported that eGFR calculated using either the IDMS–MDRD Study equation modified by using the JSN–CKDI coefficient (0.741; equation 1) or the JSN–CKDI equation (equation 2) was more accurate than the unmodified MDRD Study equation in Japanese individuals.19 The present study verifies our previous results, and accuracy of GFR estimation is improved further by means of newly derived equations, the modified IDMS–MDRD Study equation with the new Japanese coefficient (0.808; 95% CI,
Acknowledgements
Author affiliations are as follows. Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan: Seiichi Matsuo, MD, PhD, Yoshinari Yasuda, MD, PhD; Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan: Enyu Imai, MD, PhD; Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Japan: Masaru Horio, MD, PhD; Department of Nephrology, Kumamoto University, Graduate School of Medicine, Kumamoto,
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Originally published online as doi:10.1053/j.ajkd.2008.12.034 on April 2, 2009.
A list of author affiliations appears at the end of this article.
A list of the investigators who helped develop the Japanese equation for estimated GFR appears at the end of the article.