Clinical-liver, pancreas, and biliary tractContribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease
Section snippets
Survey design
Data were derived from the Third National Health and Nutrition Examination Survey (NHANES III), a cross-sectional study conducted by the National Center for Health Statistics from 1988 to 1994 to assess the health and nutritional status of the noninstitutionalized US population.18 Data included laboratory investigation results, physical examination findings, and structured questionnaires conducted in mobile examination centers at 89 locations throughout the United States.
Study sample
Of 18,827 participants
Results
Out of 9041 participants, 1037 had the following causes of chronic liver disease: 184 had viral hepatitis (136 HCV, 46 HBV, and 2 HCV and HBV), 654 had excessive alcohol consumption (in the absence of HBV or HCV), and 199 had increased TS (in the absence of HBV, HCV, or excessive alcohol consumption). The prevalence of increased ALT activity was 10.3% in those with and 3.4% in those without the causes of chronic liver disease listed previously (Table 1). Among persons without these causes of
Discussion
Our study is limited by the fact that liver tissue was not available to determine hepatic steatosis, inflammation, or fibrosis. Instead, increased ALT activity was used as a surrogate measure for the presence of liver disease as in previous population-based studies.3, 14 Therefore, we cannot confirm that the increased ALT activity that was associated with obesity, insulin resistance, or the metabolic syndrome was related to hepatic steatosis. However, previous studies have shown that most (83%)
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Development and Validation of the Framingham Steatosis Index to Identify Persons With Hepatic Steatosis
2016, Clinical Gastroenterology and HepatologyCitation Excerpt :More recently, the ALT:AST ratio has been shown to be a better surrogate marker than ALT for predicting insulin resistance in a Japanese cohort.21 In prior epidemiologic studies, elevation in ALT has most frequently been used as a surrogate marker for NAFLD.7,22 It is well-established that NAFLD may be present in those with aminotransferase levels within the normal range.6,12
Impact of increasing alanine aminotransferase levels within normal range on incident diabetes
2012, Journal of the Formosan Medical AssociationCitation Excerpt :However, directly measuring hepatic fat content using proton magnetic resonance spectroscopy and computed tomography is unlikely in routine clinical practice.9,10,25 Serum ALT appears to be the best indicator of liver fat levels.7,8,20 Elevated ALT levels are also associated with many components of insulin resistance syndrome, such as fasting glucose levels, insulin levels, leptin, adiponectin, triglycerides, cholesterol, and percentage of body fat.12
Obesity and diabetic hyperglycemia were associated with serum alanine aminotransferase activity in patients with hepatitis B infection
2010, Metabolism: Clinical and ExperimentalCitation Excerpt :Serum alanine aminotransferase (ALT) activity is a commonly used surrogate marker for the evaluation of hepatocellular damage [15]. Several epidemiologic studies have reported that obesity and diabetes are important risk factors for elevated ALT activity in individuals with no apparent underlying cause of liver disease [16-18]. The aim of the present study was to evaluate whether obesity and diabetes as well as other metabolic factors (eg, lipid profile) are associated with serum ALT activity in a population with hepatitis B infection in Taiwan.
Association between elevated aminotransferase levels and the metabolic syndrome in Northern Turkey
2010, Annals of HepatologyCitation Excerpt :Some factors like chronic hepatitis, fatty liver, cho-lelithiasis, hyperglycemia, hyperlipidemia, obesity, medications, alcohol consumption, hemochromato-sis, Wilson’s disease, and alphal-antitrypsin deficiency may affect ATLs.1-3 Moreover, some previous studies shown that the prevalence of elevated liver enzymes is higher in individuals with metabolic syndrome (MetS).4,5 The causes of elevated ATLs may change according to ethnicity, geographic region, and develop situation of countries.
Sustained Improvements in Markers of Liver Disease Severity After Hepatitis C Treatment
2020, Journal of Clinical and Experimental Hepatology
Supported by the American College of Gastroenterology, a Junior Faculty Development Award (to G.N.I.), and the General Medical Research Service of the Veterans Affairs Puget Sound Health Care System (to S.P.L. and S.E.K.).