Clinical-liver, pancreas, and biliary tractClinical, Morphologic, and Molecular Features Defining So-Called Telangiectatic Focal Nodular Hyperplasias of the Liver
Section snippets
Patients
Between July 1992 and July 2003, we saw 13 patients at the University Hospital of Bordeaux who had a hepatic resection for TFNH. For all cases included in this study, full clinical data and follow-up were available. As comparison groups, we studied FNH and adenoma/adenomatosis exhibiting typical pathologic features, at least in a part of the tumor, leading to a firm diagnosis. For the first control group, we used 28 FNHs that were collected between 1998 and June 2003. For the second, we used 17
Pathologic Features of TFNH
In our series, the diagnosis of TFNH was straightforward in 8 cases (Table 1). In these cases, 6 features were constantly present: (1) soft tumor, (2) partially preserved lobulation with maintained acinar structures, (3) centrolobular/mediolobular sinusoidal dilatation from moderate to severe (peliosis), diffuse or occupying large areas, (4) presence of portal tract-like structures containing one or several dystrophic arteries (usually less than in FNH), with (5) an inflammatory infiltrate and
Discussion
In the present series, the diagnosis of TFNH was based on pathologic examination. We used 6 criteria to define TFNH, which allowed us to individualize TFNH from adenoma and FNH. The strongest argument to suggest the diagnosis of TFNH, present in 8 cases, was the general appearance of lobulation with the presence of portal tract-like structures containing one or several arteries with a thickened wall and an inflammatory lymphocytic infiltrate, the sinusoidal dilatation, and the ductular
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Supported by the Association pour la recherche sur le Cancer (ARC no. 3108), the INSERM (Réseaux de recherche clinique et réseaux de recherche en santé des populations), the comité Dordogne de la Ligue contre le Cancer, and the SNFGE. S.R. is supported by a Ligue Nationale Contre le Cancer doctoral fellowship.