IntroductionDiagnosis and Treatment of Hepatocellular Carcinoma
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Diagnosis of Hepatocellular Carcinoma
Cirrhosis is the strongest and the most common known risk factor for hepatocellular carcinoma (HCC), particularly cirrhosis related to hepatitis C virus (HCV) and hepatitis B virus (HBV) infections.1, 2, 3 In addition, HBV acquired in the perinatal period and early childhood is associated with increased risk of HCC even in the absence of cirrhosis.
Treatment of HCC
The management of HCC involves multiple disciplines including hepatology, surgery, diagnostic and interventional radiology, oncology, and pathology. One has to consider several patient and tumor factors including the severity of underlying liver disease, tumor bulk, and associated comorbidities as well as several practice-setting factors including availability and expertise in surgical resection, transplantation, and ablative therapies.
References (103)
- et al.
Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis
Hepatology
(2003) - et al.
Improved survival with screening for hepatocellular carcinoma
Liver Transpl
(2000) - et al.
Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)
Am J Gastroenterol
(2002) - et al.
Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status
J Hepatol
(2001) - et al.
Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population
Hepatology
(1995) - et al.
Serum α-fetoprotein levels and liver histology in patients with chronic hepatitis C
Am J Gastroenterol
(1998) - et al.
Cost-effectiveness of hepatocellular carcinoma surveillance in patients with hepatitis C virus-related cirrhosis
Clin Gastroenterol Hepatol
(2005) - et al.
Hepatocellular carcinoma screening in patients waiting for liver transplantation: a decision analytic model
Liver Transpl
(2003) - et al.
Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a cost-utility analysis
Am J Gastroenterol
(2003) - et al.
MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation
Hepatology
(2003)
Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations
Liver Transpl
Clinical management of hepatocellular carcinomaConclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver
J Hepatol
Assessment of the benefits and risks of percutaneous biopsy before surgical resection of hepatocellular carcinoma
J Hepatol
Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients
Gastroenterology
Tamoxifen treatment in hepatocellular carcinoma
Gastroenterology
A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma
Hepatology
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
Gastroenterology
Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma
Gastroenterology
Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma
Hepatology
Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival
Hepatology
Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation
Am J Transplant
No treatment, resection and ethanol injection in hepatocellular carcinoma: a retrospective analysis of survival in 391 patients with cirrhosisItalian Cooperative HCC Study Group
J Hepatol
Treatment strategy for small hepatocellular carcinoma: comparison of long-term results after percutaneous ethanol injection therapy and surgical resection
Hepatology
A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
Gastroenterology
Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma ≤4 cm
Gastroenterology
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
Lancet
Chemoembolization for hepatocellular carcinoma
Gastroenterology
Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
Hepatology
A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
Gastroenterology
Racial differences in survival of hepatocellular carcinoma in the United States: a population-based study
Clin Gastroenterol Hepatol
Translational research: the study of community effectiveness in digestive and liver disorders
Gastroenterology
Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high-risk group in Taiwan
Int J Cancer
Risk factors for hepatocellular carcinoma among patients with chronic liver disease
N Engl J Med
The findings of ruptured hepatocellular carcinoma on helical CT
Br J Radiol
Glucose utilization in a patient with hepatoma and hypoglycemiaAssessment by a positron emission tomography
J Clin Invest
Erythropoietin production in hepatocellular carcinoma cells associated with polycythemia: immunohistochemical evidence
Hepatology
Tumors of the liver
Management of hepatocellular carcinoma
Hepatology
Randomized controlled trial of screening for hepatocellular carcinoma
J Cancer Res Clin Oncol
Screening for liver cancer: results of a randomised controlled trial in Qidong, China
J Med Screen
Combined α-fetoprotein testing and ultrasonography as a screening test for primary liver cancer
J Med Screen
Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
Gut
Screening for hepatocellular carcinoma
Hepatology
Detection of hepatocellular carcinomas and dysplastic nodules in cirrhotic liver: accuracy of ultrasonography in transplant patients
J Ultrasound Med
Etiologic factors and clinical presentation of hepatocellular carcinomaDifferences between cirrhotic and noncirrhotic Italian patients
Cancer
Diagnosis, staging and treatment of hepatocellular carcinoma
Braz J Med Biol Res
Detection of hepatocellular carcinoma: combined T2-weighted and dynamic gadolinium-enhanced MRI versus combined CT during arterial portography and CT hepatic arteriography
J Comput Assist Tomogr
Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass
Liver Transpl
Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging?A prospective study of 88 nodules in 34 patients
Eur J Gastroenterol Hepatol
Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver
J Comput Assist Tomogr
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