Selected SummaryHippo Tumor Supressor Pathway: Novel Implications for the Treatment of Hepatocellular Carcinoma
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Molecular mechanisms driving cancer are extremely complex. In oncology, few cancers or subtypes have shown dependency of specific genomic hits (chronic myeloid leukemia) or oncogenic addiction loops (HER2-breast cancer subclass). The classical dissection of known pathways and their implication in cancer subtypes is being completed in most cancers, but new signaling cascades are becoming relevant in the oncogenic field. The advent of whole-genome deep sequencing, on the other hand, is adding
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PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation
2013, Journal of Surgical ResearchCitation Excerpt :Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, it has the fifth highest incidence of all cancers, and is the third most common cause of cancer-related deaths worldwide [1]. Recent publications indicate that HCC cell activation by different factors is known to involve several signaling pathways including the Ras/Raf/ mitogen-activated protein kinase (MAPK) pathway, the PI3 K/AKT/mTOR pathway, the WNT/β-Catenin pathway, the Hedgehog pathway and the Hippo tumor suppression pathway [2,3]. Among them, Ras/Raf/MAPK and PI3 K/AKT/mTOR pathways appear to be the most critical in development and proliferation of HCC and are the most extensively investigated.
PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation
2012, Journal of Surgical ResearchCitation Excerpt :Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver; it ranks fifth among the most diagnosed cancers and represents the third most common cause of cancer-related deaths worldwide [1]. Recent publications indicate that HCC cell activation by different factors is known to involve several signaling pathways, including the Ras/Raf/MAPK pathway, the PI3K/AKT/mTOR pathway, the WNT/β-Catenin pathway, the Hedgehog pathway, and the Hippo tumor suppression pathway [2, 3]. Among them, the Ras/Raf/MAPK and the PI3K/AKT/mTOR pathways are the most critical pathways in the development and proliferation of HCC and have been extensively investigated.
KIBRA protein phosphorylation is regulated by mitotic kinase Aurora and protein phosphatase 1
2011, Journal of Biological ChemistryCitation Excerpt :The transcriptional coactivators YAP and TAZ function together with transcription factors such as TEAD1–4 (Scalloped in Drosophila) (10–13) to induce target gene expression, including Birc5 (8), cytokines such as connective tissue growth factor (10, 14), and the EGF family member amphiregulin (15). Accumulated evidence suggests that this emerging signaling pathway plays a critical role in cancer development with the most evident contribution to hepatocellular carcinoma (1, 2, 16). For example, mice lacking Lats1 or WW45 (ortholog of Salvador) develop several types of tumors (17–19).
Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis
2021, Cancer Cell InternationalACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma
2021, Journal of Experimental and Clinical Cancer Research