Original ResearchClinical—Alimentary TractDecreasing Risk of Colorectal Cancer in Patients With Inflammatory Bowel Disease Over 30 Years
Section snippets
Study Population
A national cohort of 7,945,116 individuals alive and residing in Denmark between 1979 and 2008 was established by use of the Danish Civil Registration System, a national demographic database with continuously updated information on name, sex, place of birth, address, marital status, and dates of immigration, emigration, and death for all Danish citizens.13 Coding of information in this and other national registers relies on the unique 10-digit personal identification number ascribed to every
Results
Overall, the Danish population contributed 178,161,458 person-years of follow-up evaluation between 1979 and 2008, during which period 32,911 individuals were diagnosed with UC (median age, 44.9 y; 53% women) and 14,463 were diagnosed with CD (median age, 35.7 y; 57% women). Demographic characteristics of the IBD patients appear in Table 1.
Discussion
The present nationwide study covering 178 million person-years of follow-up evaluation of IBD patients and non-IBD individuals in Denmark showed an increased risk of CRC among patients diagnosed with UC in the 1980s. Since then, CRC risk in Danish UC patients has declined and no longer exceeds that of persons without IBD. However, UC patients diagnosed at a young age, those with PSC, and those with long disease duration have remained at increased risk of CRC. The long-term RR of CRC in UC
References (29)
- et al.
Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies
Clin Gastroenterol Hepatol
(2012) - et al.
Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County
Clin Gastroenterol Hepatol
(2004) - et al.
Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota
Gastroenterology
(2006) - et al.
Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease
Gastroenterology
(2009) - et al.
Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998-2005
Gastroenterology
(2009) - et al.
Infliximab for inflammatory bowel disease in Denmark 1999–2005: clinical outcome and follow-up evaluation of malignancy and mortality
Clin Gastroenterol Hepatol
(2008) - et al.
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
Gut
(2001) - et al.
Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies
Am J Gastroenterol
(2005) - et al.
Intestinal inflammation and cancer
Gastroenterology
(2011) Prognosis of inflammatory bowel disease across time and countriesAn epidemiological study of population-based patient cohorts
Dan Med Bull
(2008)
The risk of inflammatory bowel disease-related colorectal carcinoma is limited: results from a nationwide nested case-control study
Am J Gastroenterol
Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark
Inflamm Bowel Dis
Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease
Gut
Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males
Gastroenterology
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This article has an accompanying continuing medical education activity on page e13. Learning Objective: Upon completion of this CME exam, successful learners will be able to discuss colorectal cancer risk in patients with inflammatory bowel disease.
Conflicts of interest The authors disclose no conflicts.
Funding Tine Jess is supported by a Female Research Leader grant (09-066323) from the Danish Council of Independent Research. The project was supported by the Aase and Ejnar Danielsen's foundation (grants 106584 and 10000139) and the Danish Cancer Society (grant R40-A1737-11-S2).