Original ResearchFull Report: Clinical-Alimentary TractCharacteristics of Missed or Interval Colorectal Cancer and Patient Survival: A Population-Based Study
Section snippets
Design
This study was approved by the Institutional Review Boards of the University of Utah and Intermountain Healthcare (IHC), and by the Resource for Genetic and Epidemiologic Research (http://www.research.utah.edu/rge/), an administrative oversight board created to govern access to the Utah Population Database (UPDB).
We performed a population-based retrospective cohort study of residents in the state of Utah, between 50 and 80 years of age, who underwent colonoscopy between February 15, 1995, and
Proportion of Interval Cancers
When combined and accounting for patients who had procedures performed in both hospital systems there were 127,205 individuals who received a colonoscopy during our study timeframe. A total of 340 patients with a history of CRC before 1995 (beginning of study window) and 14 individuals with a diagnosis of CRC more than 60 months after colonoscopy were excluded, leaving 126,851 unique individuals. There were 2659 patients who had a diagnosis of CRC at or within 60 months of their index
Discussion
This study was a US population-based study to reflect usual clinical care colonoscopy and comprises colonoscopy data from a large academic medical center and managed care organization, that together provide care to more than 85% of the state population. We found that 3.5%-6% of colorectal cancers may be "missed" at colonoscopy in usual clinical practice in Utah. The proportion of interval CRCs found in this study was nearly identical to that reported from a population-based study from Ontario,5
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Conflicts of interest These authors disclose the following: Randall Burt has been a consultant for Myriad Genetics, and N. Jewel Samadder has been a consultant for Cook Medical and Covidien, Inc. The remaining authors disclose no conflicts. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States Government.
Funding Support for this project was provided by National Cancer Institute grants P01-CA073992 (R.W.B.) and R01-CA040641 (R.W.B.), an Endoscopic Research Award from the American Society for Gastrointestinal Endoscopy (N.J.S.), and a junior faculty career development award from the American College of Gastroenterology (N.J.S.). Partial support for the Utah Population Database and this project have been provided by the Huntsman Cancer Institute Cancer Center support grant (P30CA042014) from the National Cancer Institute and the Huntsman Cancer Foundation. Support for the Utah Cancer Registry is provided by contract HHSN 261201000026C from the National Cancer Institute with additional support from the Utah Department of Health and the University of Utah.
The funding sources did not play a role in the design, conduct, or reporting of the study, or in the decision to submit the manuscript for publication.
Author names in bold designate shared co-first authorship.