Review Article
Transesophageal Echocardiography During Orthotopic Liver Transplantation: Maximizing Information Without the Distraction

https://doi.org/10.1053/j.jvca.2012.11.016Get rights and content

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Evidence-Based Effect of TEE on Anesthetic Management During OLT

TEE provides real-time visual information regarding dynamic function, volume status, overall contractility, regional wall motion, embolization of large vessels, and pericardial effusion. Several quantitative hemodynamic measurements can be obtained with TEE, including pulmonary artery (PA) pressure, cardiac output, and left atrial pressure. Because chamber pressures may be influenced by factors such as intermittent positive-pressure ventilation, pulmonary hypertension, valvular dysfunction, and

TEE Utilization and Limitations During OLT

TEE usage among liver transplantation centers is extremely variable. Wax et al22 surveyed 40 high-volume liver transplantation centers in the United States to evaluate TEE utilization. Among 217 anesthesiologists, 86% performed TEE in some or all OLT cases, with most performing a limited-scope examination. Of TEE users, 12% were board certified to perform TEE. In addition, only 1 center reported having a policy pertaining to TEE credentialing requirements. Schumann23 also conducted a survey of

Training and Proficiency

Despite the widespread availability of TEE equipment in US hospitals, <30% of anesthesiologists are formally trained in TEE techniques.10 Specific guidelines for training and certification in both basic and advanced perioperative echocardiography have been developed by the ASE/SCA in partnership with the National Board of Echocardiography. The scope of practice for basic perioperative TEE certification is focused on intraoperative monitoring rather than specific diagnosis, except in emergent

Preoperative Evaluation and TEE Safety

Morbidity from TEE insertion and manipulation ranges from lip and dental injury (13%) to mortality (0.2%).27, 28 Studies have reported that the overall odds ratio for dysphagia is 7.8 times greater for patients in whom TEE was performed and is associated with increased incidence of aspiration and length of intensive care unit stay.29, 30 Hypopharyngeal or esophageal perforation occurs infrequently (0.4%), but is associated with a high mortality rate.31 Diagnosis of TEE-associated esophageal

Preoperative TEE Assessment of Ventricular Function and Volume Status

A comprehensive TEE examination is important for baseline assessment and monitoring trends of both volume status and ventricular function as the procedure evolves. The authors refer to the 20 standard TEE views and standard probe manipulation set forth in the ASE/SCA guidelines (Fig 1).9 To obtain maximum information from this paper, the reader is encouraged to refer to these guidelines and other TEE-based references.

In the authors' experience, the most common hemodynamic changes during OLT are

TEE Examination and Surgical Phases of OLT

As previously mentioned, initial TEE examination should include documentation of the left ventricular function in all 16 segments as outlined in the ASE/SCA guidelines. Pathologic findings also may be encountered during the initial examination. For example, pleural effusions are a known complication of portal hypertension, with an estimated frequency of 5% in patients with cirrhotic ascites.42 The descending aortic SAX view allows for visualization of left-sided pleural effusions. To visualize

Pulmonary and Intracardiac Thromboembolism

Although OLT is associated with increased bleeding and altered coagulation, a prothrombotic state may occur. Impaired hepatic clearance of activated procoagulant and antifibrinolytic factors, deficiencies of anticoagulant proteins, and activation of coagulation factors as a result of venous stasis and tissue ischemia during surgical dissection and vascular clamping can generate a prothrombotic environment.54 Intravascular thrombosis formation or intracardiac thrombosis formation or both and

Conclusion

Intraoperative management of liver transplant recipients is challenging and significantly affected by cardiovascular manifestations of ESLD, coexisting cardiovascular disease processes, and acute hemodynamic derangements. Although controversy exists regarding optimal intraoperative monitoring, TEE is a powerful method for assessing hemodynamic alterations, guiding resuscitative and inotropic therapy, and identifying potential complications during OLT. The authors agree that significant data can

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References (77)

  • B.J. Spier et al.

    Review of complications in a series of patients with known gastro-esophageal varices undergoing transesophageal echocardiography

    J Am Soc Echocardiogr

    (2009)
  • J.N. Hilberath et al.

    Safety of transesophageal echocardiography

    J Am Soc Echocardiogr

    (2010)
  • A. Ng et al.

    Perioperative echocardiography for non-cardiac surgery: What is its role in routine haemodynamic monitoring?

    Br J Anaesth

    (2009)
  • D. Miller et al.

    The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance

    J Am Soc Echocardiogr

    (2004)
  • A. Howard et al.

    Estimating the volume of chronic pleural effusions using transesophageal echocardiography

    J Cardiothorac Vasc Anesth

    (2011)
  • R.H. Steadman

    Anesthesia for liver transplant surgery

    Anesthesiol Clin North Am

    (2004)
  • C. Ellenberger et al.

    Cardiovascular collapse due to massive pulmonary thromboembolism during orthotopic liver transplantation

    J Clin Anesth

    (2006)
  • E. Gologorsky et al.

    Intracardiac thrombus formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation

    Liver Transpl

    (2001)
  • M.W. Wolfe et al.

    Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism

    Am Heart J

    (1994)
  • M.V. McConnell et al.

    Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism

    Am J Cardiol

    (1996)
  • M.A. Ramsay et al.

    Severe pulmonary hypertension in liver transplant candidates

    Liver Transpl Surg

    (1997)
  • M. Castro et al.

    Frequency and clinical implications of increased pulmonary artery pressures in liver transplant patients

    Mayo Clin Proc

    (1996)
  • I.D. Harley et al.

    Orthotopic liver transplantation in two patients with hypertrophic obstructive cardiomyopathy

    Br J Anaesth

    (1996)
  • J.H. Chin et al.

    Aggravation of mitral regurgitation by calcium administration in a patient with hypertrophic cardiomyopathy during liver transplantation: A case report

    Transplant Proc

    (2009)
  • A. Robertson

    Intraoperative management of liver transplantation in patients with hypertrophic cardiomyopathy: A review

    Transplant Proc

    (2010)
  • S. Aniskevich et al.

    Dynamic left ventricular outflow tract obstruction during liver transplantation: The role of transesophageal echocardiography

    J Cardiothorac Vasc Anesth

    (2007)
  • C.G. Hughes et al.

    Postshunt hemochromatosis leading to cardiogenic shock in a patient presenting for orthotopic liver transplant: A case report

    Transplant Proc

    (2009)
  • A. Sharma et al.

    Intraoperative iatrogenic acute pericardial tamponade: Use of rescue transesophageal echocardiography in a patient undergoing orthotopic liver transplantation

    J Cardiothorac Vasc Anesth

    (2005)
  • Z.R. Brenner et al.

    Takotsubo cardiomyopathy

    Heart Lung

    (2008)
  • S.S. Eagle et al.

    Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: Separate entities or common mechanism?

    J Cardiothorac Vasc Anesth

    (2010)
  • A.K. Tiwari et al.

    Intraoperative left ventricular apical ballooning: Transient Takotsubo cardiomyopathy during orthotopic liver transplantation

    J Cardiothorac Vasc Anesth

    (2008)
  • Y. Ozier et al.

    Anesthetic management of hepatic transplantation

    Curr Opin Anaesthesiol

    (2008)
  • V.W. Xia et al.

    Incidental intracardiac thromboemboli during liver transplantation: Incidence, risk factors, and management

    Liver Transpl

    (2010)
  • R.M. Planinsic et al.

    Diagnosis and treatment of intracardiac thrombosis during orthotopic liver transplantation

    Anesth Analg

    (2004)
  • J.E. Ellis et al.

    Right heart dysfunction, pulmonary embolism, and paradoxical embolization during liver transplantation. A transesophageal two-dimensional echocardiographic study

    Anesth Analg

    (1989)
  • L.A. Fleisher et al.

    ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery

    Circulation

    (2007)
  • Practice guidelines for perioperative transesophageal echocardiography. An updated report by the American Society of Anesthesiologists and the Society of Cardiovascular Anesthesiologists Task Force on Transesophageal Echocardiography

    Anesthesiology

    (2010)
  • J.S. Shanewise et al.

    ASE/SCA guidelines for performing a comprehensive intraoperative multiplane transesophageal echocardiography examination: Recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography

    Anesth Analg

    (1999)
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    Financial support: Departmental funding.

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