Original CommunicationsThe injection of nodules of Dupuytren's disease with triamcinolone acetonide*,**
Section snippets
Materials and methods
Between January 1986 and January 1990, 63 patients (75 hands) with a diagnosis of Dupuytren's disease were evaluated and treated because of a mass in the palm. Although the conventional approach to a patient with a nodule of Dupuytren's disease is to wait until a joint contracture develops and then surgically release it, in our office patients were also given the option of intralesional injection of the nodule with triamcinolone acetonide. The nodule could be any size and there could be more
Results
In 75 hands (63 patients) undergoing triamcinolone injections into Dupuytren's nodules, all but 2 hands in 1 patient achieved regression of disease (ie, notable softening and flattening of the focus of disease). Little benefit was generally noticed after the first injection in terms of the height of the nodule; almost without exception, the nodules were found to be hard and difficult to infiltrate at the time of the initial injection. The initial injection was considered to be a priming dose.
Discussion
The concept of injecting keloids and ultimately nodules of Dupuytren's disease began to form in the 1960s. A dermatologist informed the one of us (L.D.K.) that he was using a new form of cortisone, triamcinolone, which was introduced in 1960, to treat lichens planus, a plaque-like thickening of the dermis, by intralesional injection. The author transferred the concept to injection of hypertrophic scars, an analogous thickening of the skin. He had his colleague inject half of a pruritic
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2023, Fuss und SprunggelenkCitation Excerpt :Dies endet durch physiologische Abbauprozesse schließlich in einer Volumenreduktion der Herde mit entsprechender Druckentlastung [21]. Klinische Daten zu dieser Therapieform sind speziell für die palmare Fibromatose vorhanden [6,22]. Hier konnte beispielsweise in einer Fallserie an 75 Patienten in nahezu allen Fällen eine Verbesserung der Symptomatik erreicht werden.
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2020, Journal of Clinical Orthopaedics and TraumaCitation Excerpt :None of these have shown to provide sustainable correction. One study assessed the effect of the steroid triamcinolone acetonide on 75 hands over a 4-year period.11 Patients with early disease (MCPJ <15°, normal IPJ) were selected.
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No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
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Reprint requests: Lynn D. Ketchum, MD, 5701 W 119th St, Suite 215, Overland Park, KS 66209-3721.