ArticlesInflammatory myofibroblastic tumor in children: Diagnosis and treatment☆
Section snippets
Materials and methods
Records of children who were treated for plasma cell granuloma, inflammatory pseudotumor, or IMT at our department between 1977 and 1999, inclusive, were evaluated retrospectively. Information recorded for each patient included age, sex, clinical characteristics, diagnostic procedures, treatment, histopathologic characteristics, and outcome. Histopathologic diagnosis was made by using H&E staining and immunohistochemical staining methods and by electron microscope.
Results
There were 7 children treated for IMT in the study period (Table 1).Case No. Age, Sex Presenting Symptoms Radiologic Findings Location Treatment 1 8 yr, F Dysphagia, weight loss UGI series: distal esophageal stenosis Cardioesophageal junction Proximal esophagogastrectomy plus esophagogastric anastomosis 2 10 yr, M Minor respiratory symptoms Plain chest x-ray and chest CT: Posterior mediastinal mass Right lower lung lobe Total excision 3 6 yr, M
Discussion
Inflammatory myofibroblastic tumor was first described in the in 1937, and since then has been reported at various sites such as mesentery (one of the most common extrapulmonary sites) and cardioesophageal region.1, 2, 3, 4, 8, 9, 10 It mainly is a tumor of young adults and children,4, 5 and the lung is the most frequent site of location. Histopathologically, IMT is a benign solid tumor composed mainly of spindle-shaped cells and has a chronic inflammatory component consisting of plasma cells,
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Address reprint requests to Ibrahim Karnak, MD, Department of Pediatric Surgery, Hacettepe University Medical Faculty, 06100 Ankara, Turkey.