Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients
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Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
2019, European Journal of Medicinal ChemistryCitation Excerpt :Natural ligands such as Omega-3 fatty acids (docosahexaenoic acid and eicosapentaenoic acid) of PPAR have a polar head group as carboxylic acid, linker lengthy hydrocarbon chain, and a hydrophobic tail which are necessary for tight binding with PPAR-α [9]. Dyslipidemia is treated by a synthetic agonist of PPAR-α such as fibrates which decrease the apolipoprotein C-III gene expression [100] and increase HDL cholesterol level. These drugs also responsible for decreasing triglyceride and plasma glucose levels, while in increasing insulin sensitization [101].
Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes
2007, AtherosclerosisCitation Excerpt :Probably, reducing the chronic secretory demands for pancreatic beta-cell by improving of insulin sensitivity and direct reducing of triglycerides accumulation in pancreatic islets can explain preservation of BCF in patients with T2DM by bezafibrate. Previous observations have shown beneficial effects of bezafibrate on glucose and insulin metabolism and prevention of T2DM [8,10,41–43]. The issue whether these findings influence the hard cardiovascular end-points was partially answered in patients with metabolic syndrome [44]: significant lower cardiovascular risk for these patients treated by bezafibrate was observed.
Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: Association with atherosclerosis
2007, Diabetes Research and Clinical PracticeCitation Excerpt :This result that showed serum triglycerides but not BMI is associated with insulin resistance in the patients with a BMI less than 27.0 kg/m2 has been confirmed in two of our studies [13,14]. Treatment of bezafibrate for 3 months significantly decreased serum triglyceride (277 ± 30 to 139 ± 9 mg/dl, P < 0.001), fasting glucose (163 ± 8 to 139 ± 6 mg/dl, P = 0.006), and HOMA-IR (3.61 ± 0.24 to 2.53 ± 0.20, P < 0.001), but had no effect on BMI (23.0 ± 0.4 to 23.1 ± 0.4 kg/m2, P = 0.483) [13]. Short-term (7 days) low-intensity physical exercise combined with hospital diet significantly reduced serum triglyceride (149 ± 5 to 113 ± 7 mg/dl, P = 0.004), fasting glucose (153 ± 7 to 131 ± 6 mg/dl, P = 0.014), and HOMA-IR (2.36 ± 0.17 to 1.58 ± 0.10, P = 0.001), but had no effect on BMI (23.1 ± 0.4 to 22.8 ± 0.4 kg/m2, P = 0.343) [14].
Effects of Fatty Acid Oxidation and Its Regulation on Dendritic Cell-Mediated Immune Responses in Allergies: An Immunometabolism Perspective
2021, Journal of Immunology Research