Regular ArticleEvaluating the efficacy of scalp cooling using the Penguin cold cap system to reduce alopecia in patients undergoing chemotherapy for breast cancer
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Cited by (28)
Scalp Cooling in Daily Clinical Practice for Breast Cancer Patients Undergoing Curative Chemotherapy: A Multicenter Interventional Study
2019, Asia-Pacific Journal of Oncology NursingHair disorders in patients with cancer
2019, Journal of the American Academy of DermatologyCitation Excerpt :Scalp cooling has become the most widely used method for the prevention of CIA.148 Scalp cooling systems include static devices (eg, glycerin-based, Chemocoldcaps [Chemotherapy Cold Caps, Inc, Dallas, TX], and Penguin [Penguin Cold Caps, London, United Kingdom])149,150 and dynamic scalp cooling systems that were recently cleared by the US Food and Drug Administration (DigniCap [Dignitana, Lund, Sweden], in 2015, and Orbis [Paxman Coolers Ltd, Huddersfield, United Kingdom], in 2017).151,152 The plausible mechanisms for conferring protection to the hair follicle include the reduced availability of cytotoxic drug to the hair follicle (vasoconstriction induces a decrease of 20% of scalp blood flow),127,153,154 the relative reduced follicular uptake of cytotoxic therapies,155 and decreased follicular metabolic activity.156
Patient-reported outcome assessment and objective evaluation of chemotherapy-induced alopecia
2018, European Journal of Oncology NursingCitation Excerpt :Invasive and semi-invasive measurements like scalp skin-biopsies and hair root analysis are objective, but can be unpleasant for patients and are costly and time consuming (Chamberlain and Dawber, 2003; Van Neste, 2002; Van Neste, 1999; Canfield, 1996; Donati et al., 2011). Non-invasive techniques like photography or counting shed hairs could also be useful in assessing the severity of hair loss (Chamberlain and Dawber, 2003; Van Neste, 2002; Donati et al., 2011; Massey, 2004; Peck et al., 2000; Ridderheim et al., 2003). Photography may be used to compare the difference in visible hair loss during treatment, but it is subjective and does not generate a reliable estimation for hair loss on a localized area of the scalp.
Supportive cryotherapy: A review from head to toe
2014, Journal of Pain and Symptom ManagementCitation Excerpt :Although uncommon, adverse effects include headaches,68,75 extreme coldness,69,76 or a heavy sensation.69 Rare side effects include nausea, dizziness, or anxiety.76,77 Two case reports of scalp metastases associated with scalp hypothermia in patients with hematological malignancies have been reported.78,79
Effectiveness of scalp cooling in chemotherapy
2011, Bulletin du CancerScalp cooling to prevent chemotherapy-induced alopecia
2020, Anais Brasileiros de DermatologiaCitation Excerpt :Some topicals, such as minoxidil or bimatoprost, have been shown effective in stimulation of hair regrowth after chemotherapy, with no preventive effect on CIA.29–44 Since the 1970s, a variety of scalp cooling techniques – such as cryogel bags, cold caps, and cooling machines – have been used for CIA prevention.12,25–28 Cold caps (e.g., Elasto-gel, Penguin) and electronic cooling machines (e.g., Paxman, Dignitana) are the most used worldwide.
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