Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Regular ArticleEndocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy
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2018, Archives of Biochemistry and BiophysicsCitation Excerpt :The endocannabinoid system is involved in several biological processes mainly mediated by two GPCRs, CB1 and CB2. Cannabinoid receptors play an important role in the modulation of acute nociceptive stimulation as well as in chronic pain syndromes, in which they are permanently stimulated by endocannabinoids [154,155]. Cannabinoids share several pharmacological properties with opioids and can have synergic properties.
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Correspondence to: Dr Andrew S. C. Rice, Department of Anaesthetics, Division of Surgery, Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK. Tel. GB+20-8746-8156; Fax: GB+20-8237-5109; E-mail: [email protected]