Chronische spontane Urtikaria, Adipositas und metabolische Erkrankungen

 

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Zusammenfassung

Ziel Darstellung der aktuellen Literatur und neuer Erkenntnisse zum Zusammenhang der chronisch spontanen Urtikaria (CSU) mit Adipositas-assoziierter Inflammation und metabolischen Erkrankungen.

Methodik Eine englischsprachige, Pubmed-basierte Literaturrecherche mit den Stichwörtern „chronic urticaria“ und „hypertension“, „hyperlipidemia“, „metabolic syndrome“, „metabolic diseases“, „obesity“, „overweight“, „glucose intolerance“, „diabetes“ sowie zu „cytokines“, „pro-inflammatory“, „adipokines“, „immunological dysregulation“.

Ergebnisse In der aktuellen Literatur zeigen sich erhöhte Prävalenzen für Adipositas, Diabetes mellitus, Hyperlipidämie und Hypertonie bei CSU-Patienten. Zudem zeigen sich signifikante Assoziationen zwischen metabolischen Komorbiditäten und der klinischen Ausprägung, Krankheitsdauer oder dem therapeutischen Ansprechen bei der CSU. Darüber hinaus lassen sich gemeinsame immunologische Merkmale zwischen der CSU und Adipositas erkennen, da eine Dysbalance pro- und anti-inflammatorisch wirksamer Zytokine sowie Adipokine zugunsten eines pro-inflammatorischen Zustandes bei beiden Erkrankungen vorliegt. Die Ableitung klinischer Implikationen in Hinblick auf Screening-, Präventions- oder Interventionsmaßnahmen metabolischer Erkrankungen bei der CSU sollte diskutiert werden.

Abstract

Objective The aim of this paper is to present current literature and new evidence on the association of chronic spontaneous urticaria (CSU) with obesity-associated inflammation and metabolic diseases.

Methods A Pubmed-based search was performed using the keywords „chronic urticaria“ and „hypertension“, „hyperlipidemia“, „metabolic syndrome“, „metabolic diseases“, „obesity“, „overweight“, „glucose intolerance“, „diabetes“ as well as „cytokines“, „pro-inflammatory“, „adipokines“, „immunological dysregulation“.

Results and Conclusion The current literature shows increased prevalences of obesity, diabetes mellitus, hyperlipidemia, and hypertension in CSU patients. In addition, significant associations are shown between metabolic comorbidities and clinical severity, disease duration, or therapeutic response in CSU. Furthermore, common immunological features can be identified between CSU and obesity due to a dysbalance of pro- and anti-inflammatory cytokines as well as adipokines in favor of a pro-inflammatory state in both diseases. The elaboration of clinical implications in terms of screening, prevention or intervention measures of metabolic diseases in CSU should be discussed.

Publication History

Article published online:
29 November 2022

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