DOI: 10.1055/b-002-72200
Bhandari, Mohit; Joensson, Anders: 2009

Clinical Research for Surgeons

Print ISBN 9783131439314 · Online ISBN 9783131494511
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Book

Editors: Bhandari, Mohit; Joensson, Anders

Authors: Ledet, Eric; Morshed, Saam; Petrisor, Brad; Robioneck, Bernd; Schemitsch, Emil; Sprague, Sheila; Ansell, Natalie; Busse, Jason; Chan, Simon; Dijkman, Bernadette; Duffy, Paul; Farrokhyar, Forough; Furey, Andrew J.; Goldstein, Christina; Grabowsky, Mary Beth; Karanicolas, Paul J.; Kooistra, Bauke; Kraus, Shelley; Leece, Pam; Lutz, Kristina; Mathew, George; Mundi, Raman; Poolman, Rudolf; Speller, Ryan; Zlowodzki, Michael

Title: Clinical Research for Surgeons

Print ISBN: 9783131439314; Online ISBN: 9783131494511; Book DOI: 10.1055/b-002-72200

2009 © 2009 Georg Thieme Verlag KG
Georg Thieme Verlag KG, Stuttgart

Subjects: Orthopaedics and Trauma Surgery

Thieme Clinical Collections (English Language)



Front Matter
PART I Why We Need Clinical Research
Introduction
1 Historical Perspectives of Clinical Research
2 Evidence-Based Surgery Defined
3 Myths and Misconceptions about Evidence-Based Medicine
4 Becoming an Evidence-Based Surgeon
PART II Principles of Clinical Research
Introduction
5 Various Research Design Classifications
6 Hierarchy of Research Studies: From Case Series to Meta-Analyses
7 Randomized and Nonrandomized Studies
8 The Clinical Case Series
9 The Case–Control Study
10 The Prospective Cohort Study
11 The Randomized Trial
12 Meta-Analysis
13 Economic Analysis
14 The Diagnostic Study
15 The Reliability Study
16 The Classification of Outcomes
17 What Makes an Outcome Measure Useful
18 Common Generic Outcome Scales for Surgeons
19 Common Disease-Specific Outcome Scales for Surgeons
20 Common Ways to Present Treatment Effects
21 The Confidence Interval Defined
22 The P Value Defined
23 Errors in Hypothesis Testing
24 Clinical versus Statistical Significance
PART III Practice of Clinical Research
Introduction
25 The Requirements of a Clinical Research Proposal
26 The Identification of a Good Research Question
27 How to Conduct a Comprehensive Literature Search
28 Guide to Planning a Randomized Trial
29 Guide to Planning a Nonrandomized Study
30 Study Sample Size
31 How to Budget for a Research Study
32 Research Ethics, Review Boards, and Consent Forms
33 Regulatory Issues in the Evaluation of a New Device or Drug
34 Strategies for Obtaining Research Funding
35 The Roles of the Research Team
36 The Role of a Central Methods Center
37 The Role of a Data Monitoring Committee
38 The Need for Separate Adjudication of Outcomes
39 Data Management
40 Study Case Report Forms
41 The Study Manual of Operations
42 Review of Basic Statistical Principles
43 Statistical Means and Proportions
44 Regression Analysis
45 Analysis of Variance
46 Correlation Defined
Annex