Radiofrequency Thermal Ablation of Hepatic Metastases of Adrenocortical Cancer – A Case Report and Review of the Literature

 

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Abstract

Aim: Radiofrequency thermal ablation (RFA) has shown promise as a technique for treating solid tumors. This method has been suggested as an alternative to surgery in patients with adrenocortical carcinoma (ACC).

Materials and Methods: We reviewed the literature, and report the case of a patient with stage 4 ACC who received intraoperative and percutaneous RFA of two liver metastasis according to a standard ablation protocol.

Results: Post-interventional imaging in our patient demonstrated that after both interventions, a stellar-like structure of vital tumor tissue had remained within the coagulation necrosis. This was the starting point of a fast and progressive tumor recurrence. We suspect heat-sink effects of blood vessels in the highly vascularized metastasis to cause the tumor recurrence. In literature, there are only a few reports of RFA in ACC patients. In addition, there is no large randomized trial investigating the efficacy of RFA against surgery in those patients.

Conclusions: Presently, RFA in ACC should be restricted to patients in whom surgery is contraindicated. It is necessary that strongly vascularized ACC metastases deserve a modified ablation protocol due to perfusion related cooling effects and to increase the efficacy of RFA.

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1 Both authors contributed equally to this work.

Correspondence

M. QuinklerMD 

Internal Medicine

Center for Gastroenterology

Hepatology and Endocrinology Charité Campus Mitte

Charité University Medicine Berlin

Charitéplatz 1

10117 Berlin

Germany

Phone: +49/30/450 51 41 52

Fax: +49/30/450 51 49 52

Email: marcus.quinkler@charite.de