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Horm Metab Res 1975; 7(6): 461-467
DOI: 10.1055/s-0028-1093704
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© Georg Thieme Verlag KG Stuttgart · New York

Jejunal Factor Stimulating Insulin Release in the Isolated Perfused Canine Pancreas and Jejunum[*]

R.  Eloy , J. C. Garaud , A.  Moody [**] , D.  Jaeck , J. F. Grenier
  • Unité 61 - Inserm, Department of Surgical Research and Intestinal Physiology, Strasbourg/Hautepierre, France
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

In the present study using an isolated perfused preparation of canine jejunum and pancreas, an insulin-releasing factor was found in the venous effluent of the jejunum. Insulin secretion by the pancreas rose twofold after 10% glucose was infused in the lumen of the jejunum and remained at a high level even after the stimulus was discontinued. No modification of the exocrine pancreatic secretion occurred during the insulin release, and therefore it seems unlikely that gastrin, secretin or cholecystokinin-pancreozymin were released by the jejunal mucosa. In control experiments the values of hyperglycaemia observed previously and intraluminal hyperosmolarity were tested: at these levels, they did not affect insulin secretion. The nature of this intestinal insulin-releasing factor remains unknown however, but may be identifiable when intestinal hormones in blood can be assayed reliably.

Key words

Intestinal Hormones - Insulin - Oral Glucose - Secretin - Pancreozymin - Intestinal Insulin Releasing Factor

1 This work was supported by contrat A.T.P. Inserm No. 715.4101.

1 This work was supported by contrat A.T.P. Inserm No. 715.4101.

2 Novo Research Institute Copenhagen

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