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DOI: 10.1055/s-0028-1093759
© Georg Thieme Verlag KG Stuttgart · New York
The Insulinogenic Index in Secondary Diabetes
Publication History
Publication Date:
23 December 2008 (online)
Abstract
The insulinogenic index was investigated as a possible means for distinguishing between primary and secondary diabetes. This index is defined as the ratio ΔIRI/Δ glucose, where IRI is the plasma immunoreactive insulin level determined after the administration of a prescribed oral glucose load. The insulinogenic index values as measured 30 minutes after a 50 gm glucose load were as follows in normal subjects and those with primary diabetes: normal, 1.43 ± 0.17 (Mean ± SEM); mild diabetes, 0.39 ± 0.08; and moderate diabetes, 0.08 ± 0.02. In certain diseases associated with abnormal glucose tolerance, the values were as follows; pheochromocytoma, 0.18 ± 0.12, acromegaly associated with severe glucose intolerance, 0.16 ± 0.08; acromegaly associated with mild glucose intolerance, 0.54 ± 0.20; and liver cirrhosis, 0.59 ± 0.10. These values were not significantly different from those in primary diabetes. On the other hand, in other diseases associated with abnormal glucose tolerance a marked difference was noted as follows: hyperthyroidism, 1.01 ± 0.20; Cushing's syndrome, 1.37 ± 0.42; steroid diabetes, 1.22 ± 0.32; acute hepatitis, 1.16 ± 0.31; and chronic hepatitis, 1.48 ± 0.34. It was concluded, therefore, that in the latter cases, the insulinogenic index is a supplementary tool for distinguishing between primary and secondary diabetes.
Key words
Secondary Diabetes - OGTT - ΔInsulin - ΔGlucose - Insulinogenic Index