Am J Perinatol 2009; 26(5): 331-333
DOI: 10.1055/s-0028-1104742
© Thieme Medical Publishers

An Unusual Presentation of Infantile Fibrosarcoma in a Male Newborn

Bora Gülhan1 , Serhan Küpeli2 , Bilgehan Yalçın2 , Canan Akyüz2 , Münevver Büyükpamukçu2
  • 1Department of Pediatrics, Hacettepe University, Ankara, Turkey
  • 2Institute of Oncology, Department of Pediatric Oncology, Hacettepe University, Ankara, Turkey
Further Information

Publication History

Publication Date:
09 December 2008 (online)

ABSTRACT

We describe a 10-day-old male presenting with drop foot and immobility in his right leg; no abnormality in physical examination had been found upon delivery or discharge. Magnetic resonance imaging showed a pelvic mass with an extension to the great sciatic foramen. Fine-needle aspiration biopsy revealed congenital infantile fibrosarcoma. He was started on vincristine, actinomycin-D, cyclophosphamide chemotherapy. However, he died soon after the second cycle due to veno-occlusive disease of the liver. Differential diagnosis of drop foot and immobility in lower extremity must include infiltrating neoplasms in pelvis.

REFERENCES

  • 1 Soule E H, Pritchard D J. Fibrosarcoma in infants and children: a review of 110 cases.  Cancer. 1977;  40 1711-1721
  • 2 Chung E B, Enzinger F M. Infantile fibrosarcoma.  Cancer. 1976;  38 729-739
  • 3 Lee M J, Cairns R A, Munk P L, Poon P Y. Congenital-infantile fibrosarcoma: magnetic resonance imaging findings.  Can Assoc Radiol J. 1996;  47 121-125
  • 4 Cofer B R, Vescio P J, Wiener E S. Infantile fibrosarcoma: complete excision is the appropriate treatment.  Ann Surg Oncol. 1996;  3 159-161
  • 5 Nonaka D, Sun C C. Congenital fibrosarcoma with metastasis in a fetus.  Pediatr Dev Pathol. 2004;  7 187-191
  • 6 Fisher C. Myofibroblastic malignancies.  Adv Anat Pathol. 2004;  11 190-201
  • 7 Coffin C M, Dehner L P. Fibroblastic-myofibroblastic tumors in children and adolescents: a clinicopathologic study of 108 examples in 103 patients.  Pediatr Pathol. 1991;  11 569-588
  • 8 Stout A P. Fibrosarcoma in infants and children.  Cancer. 1962;  15 1028-1040
  • 9 Yalcin B, Leblebicioğlu G, Güler E et al.. Congenital infantile fibrosarcoma of the thigh in a newborn.  Tumori. 2001;  87 436-438
  • 10 Shetty A K, Yu L C, Gardner R V, Warrier R P. Role of chemotherapy in the treatment of infantile fibrosarcoma.  Med Pediatr Oncol. 1999;  33 425-427
  • 11 Arndt C, Hawkins D, Anderson J R et al.. Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin and cyclophosphamide.  J Clin Oncol. 2004;  22 1894-1901

Serhan KüpeliM.D. 

Institute of Oncology, Department of Pediatric Oncology, Hacettepe University

Ankara, Turkey

Email: serkupeli@yahoo.com

    >