Cent Eur Neurosurg 2011; 72(2): 101-104
DOI: 10.1055/s-0030-1252010
Case Report

© Georg Thieme Verlag KG Stuttgart · New York

ALA-induced Porphyrin Accumulation in Medulloblastoma and its use for Fluorescence-Guided Surgery

S. Eicker1 , S. Sarikaya-Seiwert1 , A. Borkhardt2 , K. Gierga3 , B. Turowski4 , H.-J. Heiroth1 , H.-J. Steiger1 , W. Stummer5
  • 1Heinrich-Heine-Universität, Neurosurgery, Düsseldorf, Germany
  • 2Heinrich-Heine-Universität, Department of Paediatric Oncology, Haematology and Immunology, Düsseldorf, Germany
  • 3Heinrich-Heine-Universität, Institute of Neuropathology, Düsseldorf, Germany
  • 4Heinrich-Heine-Universität, Neurochirurgische Klinik, Düsseldorf, Germany
  • 5Universität Düsseldorf, Neurochirurgische Klinik, Düsseldorf, Germany
Further Information

Publication History

Publication Date:
07 October 2010 (online)

Introduction

Medulloblastoma is the most common malignant brain tumor in children. Most children with this disease are treated in controlled studies to improve survival and advance cure rates [6]. The current treatment includes surgical resection, radiotherapy and chemotherapy. Depending on the classification into standard-risk (age 4 years, non-metastatic dis-ease, and complete or almost complete tumor resection) and high-risk patients, the treatment options differ, ranging from postoperative chemotherapy alone [18], to postoperative chemotherapy and radiotherapy, to stem cell therapy in the case of recurrence [5]. According to the classification, maximum cytoreductive surgery appears to be essential for the efficacy of adjuvant treatment. All controlled studies so far have aimed at optimizing adjuvant therapies, i. e., chemotherapy and radiotherapy, but to our knowledge none have been devoted to improving surgery. We report the first operation performed with fluorescence guidance using 5-aminolevulinic acid (ALA) for the resection of medulloblastoma to avoid incomplete tumor resection as a favorable basis for adjuvant therapy [11].

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Correspondence

Dr. S. Eicker

Heinrich-Heine-Universität

Department of Neurosurgery

Moorenstraße 5

40225 Düsseldorf

Germany

Phone: +49/211/811 6268

Fax: +49/211/811 9556

Email: sven.eicker@med.uni-duesseldorf.de

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