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Exp Clin Endocrinol Diabetes 2011; 119(4): 257-263
DOI: 10.1055/s-0030-1269912
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Changes of Serum Omentin Levels and Relationship between Omentin and Adiponectin Concentrations in Type 2 Diabetes Mellitus

P. Yan1 , D. Liu1 , M. Long1 , Y. Ren1 , J. Pang2 , R. Li1
  • 1Department of Endocrinology, the Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
  • 2Department of Endocrine Laboratory, the Second Affiliated Hospital Chongqing Medical University, Chongqing, China
Further Information

Publication History

received 15.07.2010 first decision 18.11.2010

accepted 01.12.2010

Publication Date:
03 March 2011 (online)

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Abstract

Background: Omentin has recently been characterized as a potent insulin-sensitizing adipokine, but its pathophysiologic roles in humans remain largely unknown.

Objective: To investigate the change of fasting serum omentin levels and evaluate the relationship of omentin with adiponectin in patients with type 2 diabetes mellitus.

Design: 35 patients with newly diagnosed type 2 diabetes (T2DM), 35 patients with impaired glucose regulation (IGT) and 35 patients with normal glucose tolerance (NGT) participated in this study. Fasting serum omentin and adiponectin levels were measured by enzyme-linked immunosorbent assay. The relationship between serum omentin, serum adiponectin levels and metabolic parameters was also analyzed.

Results: Fasting serum omentin levels were significantly lower in T2DM and IGT groups than in NGT group (16.75±1.71 vs. 18.62±1.22 vs. 24.60±1.43 ng/ml, all P<0.01). Obesity subjects had significantly lower serum omentin levels than normal body weight subjects (P<0.01 or P<0.05). Female subjects had moderately higher fasting serum omentin levels than male subjects. Fasting serum adiponectin levels showed a similar variation trend to omentin in T2DM and NGT groups, obesity and normal body weight subjects, female and male subjects. Fasting serum omentin levels were negatively correlated with HOMA-IR and positively correlated with adiponectin. Moreover, HOMA-IR and adiponectin were the independently predictors of fasting serum omentin levels.

Conclusions: Serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes. More importantly, there is such a close connection between serum omentin and adiponectin levels that regulation of omentin may be dependent on adiponectin.

Key words

omentin - adiponectin - type 2 diabetes - insulin resistance associated with obesity

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Correspondence

Dr. D. Liu

Department of Endocrinology

the Second Affiliated Hospital

Chongqing University of

Medical Sciences

76 Linjiang Road

400010 Chongqing

China

Phone: +86/23/6798 5903

Phone: +86/23/6369 3191

Fax: +86/23/6369 3191

Email: ldf023023@yahoo.com.cn

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