Planta Med 2011; 77(9): 873-881
DOI: 10.1055/s-0030-1270983
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© Georg Thieme Verlag KG Stuttgart · New York

The Role of Chinese Medicine in the Treatment of Chronic Diseases in China

Miao Jiang1 , Chi Zhang1 , Hongxin Cao1 , Kelvin Chan2 , Aiping Lu1
  • 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
  • 2The University of Sydney and University of Western Sydney, Sydney, Australia
Further Information

Publication History

received Nov. 11, 2010 revised March 16, 2011

accepted March 19, 2011

Publication Date:
06 April 2011 (online)

Abstract

Chinese medicine (CM) has a long history of experience and proven successful treatment for chronic diseases and has also played an important role in the provision of health care in China. Patients with chronic diseases are happy to accept CM and physicians are willing to use CM to relieve patients suffering from chronic illnesses. The Chinese health authorities encourage CM development to meet the requirements for the treatment of chronic diseases. CM products are an essential part of medications that have a predominant role in the prevention and treatment of chronic diseases in China. A large number of CM clinical studies, including a substantial number of available randomized controlled trials and systematic reviews, have shown that CM is effective and safe in the treatment of chronic diseases. Although the efficacies of some evaluated CM therapies remain uncertain, it is worth assessing them by using CM pattern (Zheng or syndrome) differentiation to verify treatment outcomes. CM is considered to have a better safety profile compared to pharmaceutical chemicals, but inappropriate applications of CM also makes the safety issues a hot discussed subject. As a medical system, CM should be able to provide worldwide contribution for the patients who are suffering from chronic diseases. The application of CM pattern classification in diagnosis with corresponding prescribed treatment using herbal formulae in the relief of chronic diseases can be linked with modern biomedical parameters (biomarkers) as treatment outcomes. These outcome parameters, together with the patients' reported quality of life assessment, can provide innovative approaches for evidence-based estimation of the efficacy of CM treatment in chronic diseases.

References

  • 1 Health China: 2020. Ministry of Public Health of China: Internal Document. 2010
  • 2 Tang J L, Liu B Y, Ma K W. Traditional Chinese medicine.  Lancet. 2008;  372 1938-1940
  • 3 Browne D. The long march to primary health care in China: from collectivism to market economics.  Public Health. 2001;  115 2-3
  • 4 Wu C. Establishment of the community health service structure.  Chin Gen Pract. 2006;  9 365-366 , [in Chinese]
  • 5 Wang J, Kushner K, Frey 3rd J J, Ping D X, Qian N. Primary care reform in the People's Republic of China: implications for training family physicians for the world's largest country.  Fam Med. 2007;  39 639-643
  • 6 State Administration of Traditional Chinese Medicine of the People's Republic of China .China statistical yearbook of Chinese medicine. Available at. http://www.satcm.gov.cn/ Accessed March 31, 2011
  • 7 Ministry of Health of The People's Republic of China .Chinese health statistical digest 2010. Available at. http://www.moh.gov.cn/publicfiles/business/htmlfiles/zwgkzt/ptjty/digest2010/index.html?page=1/sheet017.htm Accessed March 31, 2011
  • 8 Flaws B. The treatment of modern Western diseases with Chinese medicine. Boulder; Blue Poppy Press 2005
  • 9 Liu D, Lin H, Wang X, Zhou W, Chen G, Guo W, Ye J, Xu Z, Chen H, Chen X M, Lai Z, Xiang C. Influence of removing blood stasis and tonifying liver and kidney method on quality of life in patients with essential hypertension: randomized controlled observation.  Chin J Clin Rehabil. 2006;  10 9-12 , [in Chinese]
  • 10 Yu Z, Wang G, Chen G Y, Chang J, Zhang Y, Zhang R M. Muo-luo-dan. Concentrated pill in treatment of chronic atrophic gastritis (the stomach-yin of deficiency and stagnated blood of stomach meridian): a prospective, randomized, controlled trial.  West China Med J. 2007;  22 287-289 , [in Chinese]
  • 11 Tong X L, Ni Q, Lian F M, Hu J Q, Yu F H, Ou Y, Xue Q, Jiang Z, Wu S T, Jiang H, Gao T S, Yao C, Zhao M, Zhang Y. Multi-center randomized controlled and double blind trial of Tang-min-ling pills in the treatment of type 2 diabetes mellitus.  Chin J Clin Pharmacol. 2009;  25 104-108 , [in Chinese]
  • 12 Guo F L, Han C, Liu Q P, Liu L J. Clinical observation on the effect of Tongbi Heji plus syndrome differentiation treatment for 90 rheumatoid arthritis patients.  J Tradit Chin Med. 2008;  49 897-900 , [in Chinese]
  • 13 Zhou C X, Cui X, Li X Q, Zeng H L, Ni H H, Huang C S, Wu J, Shi J C, Feng M L, Wu Y G. Clinical research on combined herbal medicine and acupuncture in treating poststroke depression.  Shanghai J Tradit Chin Med. 2010;  44 46-48 , [in Chinese]
  • 14 Qin X Y, Li X X, Suteanu S. Comparative study on Chinese medicine and Western medicine for treatment of prolapse of lumbar intervertebral disc.  Chin Acupunct Moxibustion. 2007;  27 365-368 , [in Chinese]
  • 15 Xu Y H, Wang J H, Yang F X, He X Z. The effects of respiratory rehabilitation training on pulmonary function and quality of life of patients with COPD.  Chin J Rehabil. 2010;  25 120-122 , [in Chinese]
  • 16 Qing H, Wang S F, Fan J M, Zha L H, Mao J Y, Sun L J, Zhang R L. Multi-center clinical study of Rhadiola extract injection on the treatment of stable angina pectoris of coronary heart disease with cariac blood stasis syndrome.  Chin Tradit Pat Med. 2009;  31 343-346 , [in Chinese]
  • 17 Liu T, Liu C, Gao P X, Yu C P. Clinical study on method of “tonifying the lung to check the liver” for treatment of chronic cholecystitis.  Chin Acupunct Moxibustion. 2005;  25 855-856 , [in Chinese]
  • 18 Wei J Q, Lin S R, He W N. Compared with tagamet in treating chronic gastric ulcer.  Chin J Integr Tradit West Med. 1994;  14 17-18 , [in Chinese]
  • 19 Liu J P, Yang M, Liu Y X, Wei M L, Grimsgaard S. Herbal medicines for treatment of irritable bowel syndrome.  Cochrane Database Syst Rev. 2006;  (1) CD004116
  • 20 Liu J P, Zhang M, Wang W Y, Grimsgaard S. Chinese herbal medicines for type 2 diabetes mellitus.  Cochrane Database Syst Rev. 2004;  (3) CD003642
  • 21 Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke.  Cochrane Database Syst Rev. 2007;  (2) CD004295
  • 22 Wang H, Shang H C, Zhang J H, Chen J, Sun B Z, Shang D D, Xiang Y Z, Cao H B, Ren M, Cuo L P, Zhang B L. Niuhuang Jiangya preparation for treatment of essential hypertension: a systematic review.  Liaoning J Trad Chin Med. 2008;  35 649-652 , [in Chinese]
  • 23 Wang S Z, Lin H L, Song H M, Zhong W H, Wu T X, Liu G J, Chen S Q. Conservative in the treatment of protrusion of cervical vertebra intervertebral disc: a systematic review.  Chin J Evid Based Med. 2009;  9 331-336 , [in Chinese]
  • 24 Zhou W, Zhong Y Q, Yang H M, Jiang H L, Fu J J, Zhang W B, Mao B. Traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials.  Chin J Evid Based Med. 2009;  9 311-318 , [in Chinese]
  • 25 Jin X, Wang Z R. Meta analysis of clinical research literature on supplementing qi and activating blood circulation for coronary heart disease.  J Fourth Military Med Univ. 2008;  29 1188-1190 , [in Chinese]
  • 26 Manheimer E, Wieland S, Kimbrough E, Cheng K, Berman B M. Evidence from the Cochrane Collaboration for Traditional Chinese Medicine therapies.  J Alternat Complement Med. 2009;  15 1001-1014
  • 27 Xie X S, Wang Y J, Zuo C, Fan J M, Li X J. A case report of an effective treatment for diabetic foot ulcers with integration of traditional Chinese medicine and Western medicine.  J Diabetes Complications. 2009;  23 360-364
  • 28 Zha Q L, He Y T, Ding X R, Jiang M, Liu X W, Lu C, Tsang I, Lu A P. The predictive role of symptoms/signs on ACR20 responses in rheumatoid arthritis analyzed with data mining approaches. Proceedings of the 2nd International Conference on BioMedical Engineering and Informatics, BMEI, Tianjin, China; 2009: 1 – 8. 
  • 29 Li S, Lu A, Wang Y. Symptomatic comparison in efficacy on patients with benign prostatic hyperplasia treated with two therapeutic approaches.  Complement Ther Med. 2010;  18 21-27
  • 30 Chan K. Chinese medicinal materials and their interface with Western medical concepts.  J Ethnopharmacol. 2005;  96 1-18
  • 31 Yi H G, Huang G Z, Liu G J. Efficacy and safety of levoamlodipine besylate for essential hypertension: a systematic review.  Chin J Evid Based Med. 2008;  8 543-550 , [in Chinese]
  • 32 Vipond N. Intervertebral disc replacement. Available at. http://www.acc.co.nz/PRD_EXT_CSMP/groups/external_communications/documents/reports_results/prd_ctrb091239.pdf Accessed Sep 28, 2010
  • 33 Walters J A, Walters E H, Wood-Baker R. Oral corticosteroids for stable chronic obstructive pulmonary disease.  Cochrane Database Syst Rev. 2005;  (3) CD005374
  • 34 Jun M, Foote C, Lv J, Neal B, Patel A, Nicholls S J, Grobbee D E, Cass A, Chalmers J, Perkovic V. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis.  Lancet. 2010;  375 1875-1884
  • 35 Sze S C, Wong K L, Liu W K, Ng T B, Wong J H, Cheung H P, Yow C M, Chu E S, Liu Q, Hu Y M, Tsang K W, Lee W S, Tong Y. Regulation of p 21, MMP-1, and MDR-1 expression in human colon carcinoma HT29 by Tian Xian liquid, a Chinese medicine formula, in vitro and in vivo.  Integr Cancer Ther. , advance online publication August 11, 2010; PMID: 20702488
  • 36 Zhou C Y, Tang J Y, Fang D Y. Clinical study on active rheumatoid arthritis treated with simiao xiaobi decoction.  Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;  30 275-279
  • 37 Hsieh S C, Lai J N, Chen P C, Chen C C, Chen H J, Wang J D. Is Duhuo Jisheng Tang containing Xixin safe? A four-week safety study.  Chin Med. 2010;  5 6
  • 38 Geng Q, Lu B D, Huang X J. Effect of modified tianxiong powder in treating oligospermia and asthenospermia.  Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;  30 496-498
  • 39 Zhu J, Wan X, Zhu Y, Ma X, Zheng Y, Zhang T. Evaluation of salidroside in vitro and in vivo genotoxicity.  Drug Chem Toxicol. 2010;  33 220-226
  • 40 Zhao L, Li A Y, Lv H, Liu F Y, Qi F H. Traditional Chinese medicine Ningdong granule: the beneficial effects in Tourette's disorder.  J Int Med Res. 2010;  38 169-175
  • 41 Xie J X, Hu H T, Xiao D N, Xie H Z, Zhu C B, Yang W T, Huang X X, He X J, Liang G R, Wang Z G. Safety and efficacy of Qianliean suppository for chronic prostatitis of damp-heat and blood-stasis syndrome: a randomized, single-blind, parallel controlled, multi-centered phase III clinical trial.  Zhonghua Nan Ke Xue. 2009;  15 1049-1052
  • 42 Jia G, Meng M B, Huang Z W, Qing X, Lei W, Yang X N, Liu S S, Diao J C, Hu S Y, Lin B H, Zhang R M. Treatment of functional constipation with the Yun-chang capsule: a double-blind, randomized, placebo-controlled, dose-escalation trial.  J Gastroenterol Hepatol. 2010;  25 487-493
  • 43 Deng M, Sui X Q, Zhu S B, Ma W, Xu Y, Chen Z M. Clinical observation on the treatment of atrial fibrillation with amiodarone combined with Shenmai Injection.  Chin J Integr Med. 2010;  16 453-456
  • 44 Fan A Y, Lao L, Zhang R X, Zhou A N, Berman B M. Preclinical safety evaluation of the aqueous acetone extract of Chinese herbal formula modified Huo Luo Xiao Ling Dan.  Zhong Xi Yi Jie He Xue Bao. 2010;  8 438-447
  • 45 Xu D Y, Shu J, Huang Q Y, Liu L, Zhao S P. A comparative study of the efficacy and safety Zhibitai and atorvastatin.  Zhonghua Nei Ke Za Zhi. 2010;  49 392-395
  • 46 Xu D Y, Shu J, Huang Q Y, Wasti B, Chen C, Liu L, Zhao S P. Evaluation of the lipid lowering ability, anti-inflammatory effects and clinical safety of intensive therapy with Zhibitai, a Chinese traditional medicine.  Atherosclerosis. 2010;  211 237-241
  • 47 Wang L, Zhang R M, Liu G Y, Wei B L, Wang Y, Cai H Y, Li F S, Xu Y L, Zheng S P, Wang G. Chinese herbs in treatment of influenza: a randomized, double-blind, placebo-controlled trial.  Respir Med. 2010;  104 1362-1369
  • 48 State Food and Drug Administration .2009 national annual report of adverse drug reaction surveillance. Available at. http://www.sda.gov.cn/WS01/CL0051/48201.html Accessed March 31, 2011
  • 49 Xiong X J, Wang J, He Q Y. Application status and safety countermeasures of traditional Chinese medicine injections.  Zhong Xi Yi Jie He Xue Bao. 2010;  8 307-311
  • 50 State Food and Drug Administration .Notification on the 7 technical guidelines for the production processes and re-evaluation of the safety of Chinese medicine injection. Available at. http://www.sda.gov.cn/WS01/CL0058/54917.html Accessed March 31, 2011
  • 51 Chan K, Cheung L. Interactions between Chinese herbal medicinal products and orthodox drugs. Reading; Harwood Academic Publishers, The Gordon & Breach Publishing Group 2000
  • 52 Wang J, van der Heijden R, Spruit S, Hankermeier T, Chan K, van der Greef J, Xu G, Wang M. Quality and safety of Chinese herbal medicines guided by a systems biology perspective.  J Ethnopharmacol. 2009;  126 31-41
  • 53 Chan K. Some aspects of toxic contaminants in herbal medicines.  Chemosphere. 2003;  52 1361-1371
  • 54 Zhou J, Zhu Q, Yang X. Clinical observation of side effects of Tripterygium preparation.  Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999;  19 77-79
  • 55 Tong Y, Zhang L, Yang J, Yang L, Wang Y, Qu J, Zhang C. Retrospective study of adverse reactions of Niuhuang Jiedu tablet (pill) and risk control based on literature analysis.  Zhongguo Zhong Yao Za Zhi. 2010;  35 1342-1345
  • 56 Jiang M, Zhao J, Lu A, Zha Q, He Y. Does gastrointestinal adverse drug reaction influence therapeutic effect in the treatment of rheumatoid arthritis?.  J Alternat Complement Med. 2010;  16 143-144
  • 57 Lu A P, Ding X R, Chen K J. Current situation and progress in integrative medicine in China.  Chin J Integr Med. 2008;  14 234-240
  • 58 Lu A P, Jia H W, Xiao C, Lu Q P. Theory of traditional Chinese medicine and therapeutic method of diseases.  World J Gastroenterol. 2004;  10 1854-1856
  • 59 He Y, Lu A, Zha Y, Yan X, Song Y, Zeng S, Liu W, Zhu W, Su L, Feng X, Qian X, Lu C. Correlations between symptoms as assessed in traditional Chinese medicine (TCM) and ACR20 efficacy response: a comparison study in 396 patients with rheumatoid arthritis treated with TCM or Western medicine.  J Clin Rheumatol. 2007;  13 317-321
  • 60 Jiang M, Yang J, Zhang C, Liu B, Chan K, Cao H, Lu A. Clinical studies with traditional Chinese medicine in the past decade and future research and development.  Planta Med. 2010;  76 2048-2064
  • 61 Tan Y, Guo H T, Zheng G, Zhang C, Yang J, Lu C, Zha Q L, Jiang M, Lu A Pl. Based on text mining techniques to explore medication regularities of disease treatment with traditional Chinese medicine.  World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica. 2010;  12 823-827 , [in Chinese]
  • 62 Lu Y B, Li L, Wang Z, Zheng G, Guo H T, Jiang M, Lu A Pl. Medication regularity of tradtional Chinese medicine against rheumatoid arthritis, gout and osteoarthritis.  World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica. 2010;  12 833-836 , [in Chinese]
  • 63 Lu A P, Li S. Principle and application of Chinese medicine syndrome differentiation and disease classification.  Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;  30 84-86
  • 64 Chen G, Liu B, Jiang M, Tan Y, Lu A P. Systems biology approaches predict functional networks for Salvia miltiorrhiza and Panax notoginseng in combination.  J Med Plant Res. ;  , in press
  • 65 Wang J S, Van der Heijden R, Spruit S, Hankermeier, Chan K, Van der Greef J, Xu G W, Wang M. Quality and safety of Chinese medicine herbal medicines guided by a systems biology perspective.  J Ethnopharmacol. 2009;  126 31-41

Prof. Kelvin Chan

HMREC Faculty of Pharmacy
The University of Sydney and CompleMED College of Health & Science
University of Western Sydney

Locked Bag 1797

Penrith NSW 2751

Australia

Phone: +61 2 91 14 14 85

Fax: +61 2 46 20 32 91

Email: kelvin.chan@sydney.edu.au

Prof. Aiping Lu

China Academy of Chinese Medical Sciences

Nnaxiaojie 16#, Dongzhimennei

Beijing 100700

China

Phone: +86 10 64 06 76 11

Fax: +86 10 84 03 28 81

Email: lap64067611@126.com

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