Semin Neurol 2013; 33(02): 142-156
DOI: 10.1055/s-0033-1348960
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neurorehabilitation in Disorders of Consciousness

Joseph T. Giacino
1   Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts
2   Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts
,
Douglas I. Katz
3   Department of Neurology, Boston University Medical School, Boston, Massachusetts
4   Acquired Brain Injury Program, Braintree Rehabilitation, Braintree, Massachusetts
,
John Whyte
5   Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Elkins Park, Pennsylvania
› Author Affiliations
Further Information

Publication History

Publication Date:
25 July 2013 (online)

Abstract

Survivors of severe acquired brain injury often experience prolonged disturbance in consciousness following emergence from coma. Most individuals pass through the vegetative or minimally conscious states en route to eventual recovery of consciousness, although either condition may be permanent. Rehabilitation clinicians charged with the care of these patients face numerous challenges as there are many open questions concerning diagnostic and prognostic accuracy, the natural history of recovery, and the most effective approaches to prevent medical complications and facilitate functional recovery. The last 5 years have been witness to a marked increase in well-designed empirical investigations concerning the rehabilitation of patients with disorders of consciousness. In this article, the authors review recent evidence concerning key factors that influence the course of recovery, present a model of care designed to mitigate medical complications, describe a systematic approach to assessment, and review the effectiveness of treatment interventions utilized in the rehabilitation setting.

 
  • References

  • 1 Stuss DT, Binns MA, Carruth FG , et al. The acute period of recovery from traumatic brain injury: posttraumatic amnesia or posttraumatic confusional state?. J Neurosurg 1999; 90 (4) 635-643
  • 2 Katz DI, Polyak M, Coughlan D, Nichols M, Roche A. Natural history of recovery from brain injury after prolonged disorders of consciousness: outcome of patients admitted to inpatient rehabilitation with 1-4 year follow-up. Prog Brain Res 2009; 177: 73-88
  • 3 Sherer M, Yablon SA, Nakase-Richardson R. Patterns of recovery of posttraumatic confusional state in neurorehabilitation admissions after traumatic brain injury. Arch Phys Med Rehabil 2009; 90 (10) 1749-1754
  • 4 Plum FPJ. The diagnosis of stupor and coma. 3rd ed. Philadelphia, PA: F.A. Davis; 1982
  • 5 Medical aspects of the persistent vegetative state (1). The Multi-Society Task Force on PVS. N Engl J Med 1994; 330 (21) 1499-1508
  • 6 Giacino JT, Zasler ND, Katz DI, Kelly JP, Rosenberg JH, Filley CM. Development of practice guidelines for assessment and management of the vegetative and minimally conscious states. J Head Trauma Rehabil 1997; 12: 79-89
  • 7 Laureys SCG, Cohadon F, Lavrijsen J , et al. The European Task Force on Disorders of Consciousness. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med 2010; 8: 6-8
  • 8 The Quality Standards Subcommittee of the American Academy of Neurology. Practice parameters: assessment and management of patients in the persistent vegetative state (summary statement). Neurology 1995; 45 (5) 1015-1018
  • 9 Giacino JT, Ashwal S, Childs N , et al. The minimally conscious state: definition and diagnostic criteria. Neurology 2002; 58 (3) 349-353
  • 10 Povlishock JT, Katz DI. Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehabil 2005; 20 (1) 76-94
  • 11 Nakase-Richardson R, Yablon SA, Sherer M, Evans CC, Nick TG. Serial yes/no reliability after traumatic brain injury: implications regarding the operational criteria for emergence from the minimally conscious state. J Neurol Neurosurg Psychiatry 2008; 79 (2) 216-218
  • 12 Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974; 2 (7872) 81-84
  • 13 American Congress of Rehabilitation Medicine, Brain Injury-Interdisciplinary Special Interest Group, Disorders of Consciousness Task Force, et al. Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Arch Phys Med Rehabil 2010; 91 (12) 1795-1813
  • 14 Giacino JT, Kalmar K, Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehabil 2004; 85 (12) 2020-2029
  • 15 Wilde EAWG, Whiteneck GG, Bogner J , et al. Recommendations for the use of common outcome measures in traumatic brain injury research. Arch Phys Med Rehabil 2010; 91 (11) 1650-1660 , e17
  • 16 Schnakers CMS, Majerus S, Giacino J , et al. A French validation study of the Coma Recovery Scale-Revised (CRS-R). Brain Inj 2008; 22 (10) 786-792
  • 17 Smart CM, Giacino JT, Cullen T , et al. A case of locked-in syndrome complicated by central deafness. Nat Clin Pract Neurol 2008; 4 (8) 448-453
  • 18 Coleman MR, Davis MH, Rodd JM , et al. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain 2009; 132 (Pt 9) 2541-2552
  • 19 Newcombe VFWG, Williams GB, Scoffings D , et al. Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications. J Neurol Neurosurg Psychiatry 2010; 81 (5) 552-561
  • 20 Giacino JT, Kalmar KA. The vegetative and minimally conscious states: a comparison of clinical features and functional outcome during the first year post-injury. J Head Trauma Rehabil 1997; 12 (4) 36-51
  • 21 Vanhaudenhuyse A, Schnakers C, Brédart S, Laureys S. Assessment of visual pursuit in post-comatose states: use a mirror. J Neurol Neurosurg Psychiatry 2008; 79 (2) 223
  • 22 Schnakers C, Hustinx R, Vandewalle G , et al. Measuring the effect of amantadine in chronic anoxic minimally conscious state. J Neurol Neurosurg Psychiatry 2008; 79 (2) 225-227
  • 23 Schiff ND, Giacino JT, Kalmar K , et al. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007; 448 (7153) 600-603
  • 24 DiPasquale MC, Whyte J. The use of quantitative data in treatment planning for minimally conscious patients. J Head Trauma Rehabil 1996; 11 (6) 9-17
  • 25 Whyte J, Dipasquale MC, Vaccaro M. Assessment of command-following in minimally conscious brain injured. Arch Phys Med Rehabil 1999; 80: 653-660
  • 26 Schnakers C, Vanhaudenhuyse A, Giacino J , et al. Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol 2009; 9: 35
  • 27 Andrews K, Murphy L, Munday R, Littlewood C. Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit. BMJ 1996; 313 (7048) 13-16
  • 28 Childs NL, Mercer WN, Childs HW. Accuracy of diagnosis of persistent vegetative state. Neurology 1993; 43 (8) 1465-1467
  • 29 Tresch DD, Sims FH, Duthie EH, Goldstein MD, Lane PS. Clinical characteristics of patients in the persistent vegetative state. Arch Intern Med 1991; 151 (5) 930-932
  • 30 Giacino JT, Schnakers C, Rodriguez-Moreno D, Kalmar K, Schiff N, Hirsch J. Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold?. Prog Brain Res 2009; 177: 33-48
  • 31 Soddu A, Boly M, Nir Y , et al. Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness. Prog Brain Res 2009; 177: 261-274
  • 32 Goldfine AM, Victor JD, Conte MM, Bardin JC, Schiff ND. Determination of awareness in patients with severe brain injury using EEG power spectral analysis. Clin Neurophysiol 2011; 122 (11) 2157-2168
  • 33 Schiff ND, Rodriguez-Moreno D, Kamal A , et al. fMRI reveals large-scale network activation in minimally conscious patients. Neurology 2005; 64 (3) 514-523
  • 34 Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD. Detecting awareness in the vegetative state. Science 2006; 313 (5792) 1402
  • 35 Monti MM, Vanhaudenhuyse A, Coleman MR , et al. Willful modulation of brain activity in disorders of consciousness. N Engl J Med 2010; 362 (7) 579-589
  • 36 Migraine: clinical characteristics, epidemiology, and comorbidity. Headache 2004; 44: 628-632
  • 37 Bardin JC, Fins JJ, Katz DI , et al. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 2011; 134 (Pt 3) 769-782
  • 38 Ashwal S, Cranford R. Medical aspects of the persistent vegetative state—a correction. The Multi-Society Task Force on PVS. N Engl J Med 1995; 333 (2) 130
  • 39 Luauté J, Maucort-Boulch D, Tell L , et al. Long-term outcomes of chronic minimally conscious and vegetative states. Neurology 2010; 75 (3) 246-252
  • 40 Estraneo A, Moretta P, Loreto V, Lanzillo B, Santoro L, Trojano L. Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. Neurology 2010; 75 (3) 239-245
  • 41 Nakase-Richardson RWJ, Giacino JT , et al. Longitudinal outcome of patients with disordered consciousness in the NIDRR TBI Model Systems programs. J Neurotrauma 2012; 29 (1) 59-65
  • 42 Volker J, Semih A, Sebastian G , et al. System development for spectroscopic optical coherence tomography. Biomed Tech (Berl) 2012;
  • 43 Childs NL, Mercer WN. Brief report: late improvement in consciousness after post-traumatic vegetative state. N Engl J Med 1996; 334 (1) 24-25
  • 44 Rappaport M, Hall KM, Hopkins K, Belleza T, Cope DN. Disability rating scale for severe head trauma: coma to community. Arch Phys Med Rehabil 1982; 63 (3) 118-123
  • 45 Fischer C, Luauté J, Adeleine P, Morlet D. Predictive value of sensory and cognitive evoked potentials for awakening from coma. Neurology 2004; 63 (4) 669-673
  • 46 Nakase-Richardson R, Whyte J, Giacino JT , et al. Longitudinal outcome of patients with disordered consciousness in the NIDRR TBI Model Systems programs. J Neurotrauma 2012; 29 (1) 59-65
  • 47 Lammi MH, Smith VH, Tate RL, Taylor CM. The minimally conscious state and recovery potential: a follow-up study 2 to 5 years after traumatic brain injury. Arch Phys Med Rehabil 2005; 86 (4) 746-754
  • 48 Hamilton BBGC, Sherwin FS, Zielezny M, Tashman JS. A Uniform National Data System for Medical Rehabilitation. Baltimore, MD: Brooks; 1987
  • 49 Whyte J, Nakase-Richardson R, Hammond F , et al. Functional outcomes in traumatic disorders of consciousness: 5-year outcomes from NIDRR traumatic brain injury model systems. Arch Phys Med Rehabil , in press
  • 50 Giacino JT, Whyte J, Bagiella E , et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 2012; 366 (9) 819-826
  • 51 Whyte J, Myers R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. Am J Phys Med Rehabil 2009; 88 (5) 410-418
  • 52 Whyte J, Ponsford J, Watanabe T, Hart T. Traumatic brain injury. In: DeLisa JA, , ed. Physical Medicine and Rehabilitation: Principles and Practice. Philadelphia, PA: Lippincott, Williams & Wilkins; 2010: 575-624
  • 53 Whyte J, Nordenbo A, Kalmar K , et al. Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness. Arch Phys Med Rehabil , in press
  • 54 Schnakers C, Chatelle C, Vanhaudenhuyse A , et al. The Nociception Coma Scale: a new tool to assess nociception in disorders of consciousness. Pain 2010; 148 (2) 215-219
  • 55 Wang MC, Temkin NR, Deyo RA, Jurkovich GJ, Barber J, Dikmen S. Timing of surgery after multisystem injury with traumatic brain injury: effect on neuropsychological and functional outcome. J Trauma 2007; 62 (5) 1250-1258
  • 56 Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. [Review] Lancet Neurol 2011; 10 (10) 931-941
  • 57 Shavelle RM, Strauss D, Whyte J, Day SM, Yu YL. Long-term causes of death after traumatic brain injury. Am J Phys Med Rehabil 2001; 80 (7) 510-516 , quiz 517–519
  • 58 McNamee S, Howe L, Nakase-Richardson R, Peterson M. Treatment of disorders of consciousness in the Veterans Health Administration polytrauma centers. J Head Trauma Rehabil 2012; 27 (4) 244-252
  • 59 Eifert B, Maurer-Karattup P, Schorl M. Integration of intensive care treatment and neurorehabilitation in patients with disorders of consciousness. Arch Phys Med Rehabil , in press
  • 60 The Mohonk Report: Disorders of Consciousness: Assessment, Treatment and Research Needs: A Report to Congress. 2006. Available at: http://www.northeastcenter.com/the-mohonk-report-disorders-of-consciousness-assessment-treatment-research-needs.pdf . Accessed October 23, 2012
  • 61 Medical aspects of the persistent vegetative state (2). The Multi-Society Task Force on PVS. N Engl J Med 1994; 330 (22) 1572-1579
  • 62 The Multi-Society Task Force on PVS. The Multi-Society Task Force Report on PVS: Medical aspects of the persistent vegetative state. N Engl J Med 1994; 330 (21) 1499-1508
  • 63 Nakase-Richardson R, Whyte J, Giacino J , et al. Longitudinal outcome of patients with disordered consciousness in the NIDRR TBI Model Systems Programs. J Neurotrauma 2011; 28: 1-8
  • 64 Leong B. The vegetative and minimally conscious states in children: spasticity, muscle contracture and issues for physiotherapy treatment. Brain Inj 2002; 16 (3) 217-230
  • 65 Timmons M, Gasquoine L, Scibak JW. Functional changes with rehabilitation of very severe traumatic brain injury survivors. J Head Trauma Rehabil 1987; 2: 64-67
  • 66 Tanhehco J, Kaplan PE. Physical and surgical examination of patient after 6-year coma. Arch Phys Med Rehabil 1982; 63 (1) 36-38
  • 67 Hall ME, MacDonald S, Young GC. The effectiveness of directed multisensory stimulation versus non-directed stimulation in comatose CHI patients: pilot study of a single subject design. Brain Inj 1992; 6 (5) 435-445
  • 68 Wilson SLPG, Powell GE, Elliott K, Thwaites H. Sensory stimulation in prolonged coma: four single case studies. Brain Inj 1991; 5 (4) 393-400
  • 69 Pierce JP, Lyle DM, Quine S, Evans NJ, Morris J, Fearnside MR. The effectiveness of coma arousal intervention. Brain Inj 1990; 4 (2) 191-197
  • 70 Wood RL, Winkowski TB, Miller JL, Tierney L, Goldman L. Evaluating sensory regulation as a method to improve awareness in patients with altered states of consciousness: a pilot study. Brain Inj 1992; 6 (5) 411-418
  • 71 Formisano R, Vinicola V, Penta F, Matteis M, Brunelli S, Weckel JW. Active music therapy in the rehabilitation of severe brain injured patients during coma recovery. Ann Ist Super Sanita 2001; 37 (4) 627-630
  • 72 Wilson SLPG, Powell GE, Brock D, Thwaites H. Vegetative state and responses to sensory stimulation: an analysis of 24 cases. Brain Inj 1996; 10 (11) 807-818
  • 73 Giacino JT. Rehabilitation of patients with disorders of consciousness. In: High W, Sander A, Struchen M, Hart K, , eds. Rehabilitation for Traumatic Brain Injury. New York, NY: Oxford University Press; 2005: 305-337
  • 74 Lombardi F, Taricco M, De Tanti A, Telaro E, Liberati A. Sensory stimulation for brain injured individuals in coma or vegetative state. Cochrane Database Syst Rev 2002; (2) CD001427
  • 75 Johnson DA, Roethig-Johnston K, Richards D. Biochemical and physiological parameters of recovery in acute severe head injury: responses to multisensory stimulation. Brain Inj 1993; 7 (6) 491-499
  • 76 Meythaler JM, Brunner RC, Johnson A, Novack TA. Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial. J Head Trauma Rehabil 2002; 17 (4) 300-313
  • 77 Patrick PD, Blackman JA, Mabry JL, Buck ML, Gurka MJ, Conaway MR. Dopamine agonist therapy in low-response children following traumatic brain injury. J Child Neurol 2006; 21 (10) 879-885
  • 78 Powell JH, al-Adawi S, Morgan J, Greenwood RJ. Motivational deficits after brain injury: effects of bromocriptine in 11 patients. J Neurol Neurosurg Psychiatry 1996; 60 (4) 416-421
  • 79 Passler MARR, Riggs RV. Positive outcomes in traumatic brain injury-vegetative state: patients treated with bromocriptine. Arch Phys Med Rehabil 2001; 82 (3) 311-315
  • 80 Martin RT, Whyte J. The effects of methylphenidate on command following and yes/no communication in persons with severe disorders of consciousness: a meta-analysis of n-of-1 studies. Am J Phys Med Rehabil 2007; 86 (8) 613-620
  • 81 Matsuda W, Komatsu Y, Yanaka K, Matsumura A. Levodopa treatment for patients in persistent vegetative or minimally conscious states. Neuropsychol Rehabil 2005; 15 (3-4) 414-427
  • 82 Koeda T, Takeshita K. A case report of remarkable improvement of motor disturbances with L-dopa in a patient with post-diffuse axonal injury. Brain Dev 1998; 20 (2) 124-126
  • 83 Fridman EA, Krimchansky BZ, Bonetto M , et al. Continuous subcutaneous apomorphine for severe disorders of consciousness after traumatic brain injury. Brain Inj 2010; 24 (4) 636-641
  • 84 Clauss R, Nel W. Drug induced arousal from the permanent vegetative state. NeuroRehabilitation 2006; 21 (1) 23-28
  • 85 Shames JL, Ring H. Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report. Arch Phys Med Rehabil 2008; 89 (2) 386-388
  • 86 Brefel-Courbon C, Payoux P, Ory F , et al. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann Neurol 2007; 62 (1) 102-105
  • 87 Cohen SI, Duong TT. Increased arousal in a patient with anoxic brain injury after administration of zolpidem. Am J Phys Med Rehabil 2008; 87 (3) 229-231
  • 88 Whyte J, Myers R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. Am J Phys Med Rehabil 2009; 88 (5) 410-418
  • 89 Singh R, McDonald C, Dawson K , et al. Zolpidem in a minimally conscious state. Brain Inj 2008; 22 (1) 103-106
  • 90 Sarà M, Pistoia F, Mura E, Onorati P, Govoni S. Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. Arch Phys Med Rehabil 2009; 90 (7) 1245-1249
  • 91 Taira T. Intrathecal administration of GABA agonists in the vegetative state. Prog Brain Res 2009; 177: 317-328
  • 92 Giacino JT, Whyte J, Bagiella E , et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 2012; 366 (9) 819-826
  • 93 Hagen C, Durham P. Levels of cognitive function. In: Rehabilitation of the Head-Injured Adult: Comprehensive Physical Management. Downey, CA: Professional Staff Association of Rancho Los Amigos Hospital Inc; 1979
  • 94 Rappaport M, Dougherty AM, Kelting DL. Evaluation of coma and vegetative states. Arch Phys Med Rehabil 1992; 73 (7) 628-634
  • 95 Ansell BJ, Keenan JE. The Western Neuro Sensory Stimulation Profile: a tool for assessing slow-to-recover head-injured patients. Arch Phys Med Rehabil 1989; 70 (2) 104-108
  • 96 Taira T, Hori T. Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. Acta Neurochir Suppl (Wien) 2007; 97 (Pt 1) 227-229
  • 97 Kawecki Z, Kwiatkowski S, Grzegorzewski P, Szlachta Jezioro I. [Sudden improvement of all neurological functions after general anesthesia and two-day intrathecal infusion of baclofen in a child with primary brain-stem injury]. Przegl Lek 2007; 64 (Suppl. 02) 13-14
  • 98 Schiff ND. Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends Neurosci 2010; 33 (1) 1-9
  • 99 Moruzzi G, Magoun HW. Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1949; 1 (4) 455-473
  • 100 Kanno T, Kamei Y, Yokoyama T, Jain VK. Neurostimulation for patients in vegetative status. Pacing Clin Electrophysiol 1987; 10 (1 Pt 2) 207-208
  • 101 Tsubokawa T, Yamamoto T, Katayama Y, Hirayama T, Maejima S, Moriya T. Deep-brain stimulation in a persistent vegetative state: follow-up results and criteria for selection of candidates. Brain Inj 1990; 4 (4) 315-327
  • 102 Yamamoto T, Katayama Y. Deep brain stimulation therapy for the vegetative state. Neuropsychol Rehabil 2005; 15 (3-4) 406-413
  • 103 Kanno T, Morita I, Yamaguchi S , et al. Dorsal column stimulation in persistent vegetative state. Neuromodulation 2009; 12 (1) 33-38
  • 104 Kobayashi M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Lancet Neurol 2003; 2 (3) 145-156
  • 105 Louise-Bender Pape T, Rosenow J, Lewis G, Ahmed G , et al. Repetitive transcranial magnetic stimulation-associated neurobehavioral gains during coma recovery. Brain Stimul 2009; 2: 22-35
  • 106 Piccione F, Cavinato M, Manganotti P , et al. Behavioral and neurophysiological effects of repetitive transcranial magnetic stimulation on the minimally conscious state: a case study. Neurorehabil Neural Repair 2011; 25 (1) 98-102